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Negatively charged gold nanoparticles inhibit Alzheimer's amyloid-β fibrillization, induce fibril dissociation, and mitigate neurotoxicity
- Source :
- Small (Weinheim an der Bergstrasse, Germany). 8(23)
- Publication Year :
- 2012
-
Abstract
- Amyloids are pathogenic hallmarks in many neurodegenerative diseases such as amyloid-β (Aβ) fibrils in Alzheimer's disease (AD). Here, the effect of gold nanoparticles (AuNPs) on amyloids is examined using Aβ as a model system. It is found that bare AuNPs inhibited Aβ fibrillization to form fragmented fibrils and spherical oligomers. Adding bare AuNPs to preformed Aβ fibrils results in ragged species where AuNPs bind preferentially to fibrils. Similar results are demonstrated with carboxyl- but not amine-conjugated AuNPs. Co-incubation of negatively charged AuNPs with Aβ relieved Aβ toxicity to neuroblastoma. Overall, it is demonstrated that AuNPs possessing negative surface potential serve as nano-chaperones to inhibit and redirect Aβ fibrillization, which could contribute to applications for AD.
- Subjects :
- Amyloid
Materials science
Amyloid β
Cell Survival
S amyloid
Metal Nanoparticles
Model system
macromolecular substances
Fibril
Dissociation (chemistry)
Biomaterials
Neuroblastoma
Microscopy, Electron, Transmission
Alzheimer Disease
medicine
Tumor Cells, Cultured
Humans
General Materials Science
Cell survival
Amyloid beta-Peptides
Neurotoxicity
General Chemistry
medicine.disease
Biochemistry
Colloidal gold
Biophysics
Gold
Biotechnology
Subjects
Details
- ISSN :
- 16136829
- Volume :
- 8
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Small (Weinheim an der Bergstrasse, Germany)
- Accession number :
- edsair.doi.dedup.....1481ef8ad52fc9d09cb2fad9142f9c07