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The integrated National NeuroAIDS Tissue Consortium database: a rich platform for neuroHIV research
- Source :
- Database: The Journal of Biological Databases and Curation
- Publication Year :
- 2019
- Publisher :
- Oxford University Press, 2019.
-
Abstract
- Herein we present major updates to the National NeuroAIDS Tissue Consortium (NNTC) database. The NNTC's ongoing multisite clinical research study was established to facilitate access to ante-mortem and post-mortem data, tissues and biofluids for the neurohuman immunodeficiency virus (HIV) research community. Recently, the NNTC has expanded to include data from the central nervous system HIV Antiretroviral Therapy Effects Research (CHARTER) study. The data and biospecimens from CHARTER and NNTC cohorts are available to qualified researchers upon request. Data generated by requestors using NNTC biospecimens and tissues are returned to the NNTC upon the conclusion of requestors' work, and this external, experimental data are annotated and curated in the publically accessible NNTC database, thereby extending the utility of each case. A flexible and extensible database ontology allows the integration of disparate data sets, including external experimental data, clinical neuropsychological and neuromedical testing data, tissue pathology and neuroimaging data.
- Subjects :
- Adult
Male
AIDS Dementia Complex
Biomedical Research
Databases, Factual
Computer science
Human immunodeficiency virus (HIV)
HIV Infections
Ontology (information science)
computer.software_genre
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Immunodeficiency virus
03 medical and health sciences
Research community
medicine
Humans
030304 developmental biology
Biological Specimen Banks
0303 health sciences
Internet
Database
030302 biochemistry & molecular biology
Experimental data
Middle Aged
Antiretroviral therapy
3. Good health
Disparate system
Database Update
Database Management Systems
Female
General Agricultural and Biological Sciences
computer
Software
Information Systems
Subjects
Details
- Language :
- English
- ISSN :
- 17580463
- Volume :
- 2019
- Database :
- OpenAIRE
- Journal :
- Database: The Journal of Biological Databases and Curation
- Accession number :
- edsair.doi.dedup.....14800be30fe5420f76584f061552db62