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Angiogenic microspheres promote neural regeneration and motor function recovery after spinal cord injury in rats
- Source :
- Scientific Reports
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- This study examined sustained co-delivery of vascular endothelial growth factor (VEGF), angiopoietin-1 and basic fibroblast growth factor (bFGF) encapsulated in angiogenic microspheres. These spheres were delivered to sites of spinal cord contusion injury in rats, and their ability to induce vessel formation, neural regeneration and improve hindlimb motor function was assessed. At 2–8 weeks after spinal cord injury, ELISA-determined levels of VEGF, angiopoietin-1, and bFGF were significantly higher in spinal cord tissues in rats that received angiogenic microspheres than in those that received empty microspheres. Sites of injury in animals that received angiogenic microspheres also contained greater numbers of isolectin B4-binding vessels and cells positive for nestin or β III-tubulin (P P
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Angiogenesis
Basic fibroblast growth factor
Neovascularization, Physiologic
Hindlimb
Motor Activity
Article
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Neural Stem Cells
Polylactic Acid-Polyglycolic Acid Copolymer
Internal medicine
medicine
Animals
Lactic Acid
Spinal cord injury
Spinal Cord Injuries
Multidisciplinary
business.industry
Neurogenesis
Organ Size
Recovery of Function
Nestin
medicine.disease
Spinal cord
Magnetic Resonance Imaging
White Matter
Axons
Microspheres
Ephrin-A3
Nerve Regeneration
Up-Regulation
Surgery
Vascular endothelial growth factor
MicroRNAs
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Spinal Cord
chemistry
Anisotropy
Female
business
Polyglycolic Acid
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....147f53be088e324071ffbf54aa1a1d7e