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Surgical Management of the Succinate Dehydrogenase–Associated Familial Paraganglioma Syndromes
- Source :
- Archives of Surgery. 147:89
- Publication Year :
- 2012
- Publisher :
- American Medical Association (AMA), 2012.
-
Abstract
- Paragangliomas are rare neuroendocrine tumors arising from the neural crest cells in the extra-adrenal location. Paragangliomas can be sporadic or associated with a range of endocrine and genetic syndromes in 25% to 30% of all cases. Specifically, succinate dehydrogenase gene mutations are involved in the development of paraganglioma syndromes type 1 through type 4. In this article, we will describe 2 cases of succinate dehydrogenase-associated familial paraganglioma syndrome and provide a review of the existing literature on the condition's etiologic factors, diagnosis, and management.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Familial Paraganglioma
Gene mutation
Neuroendocrine tumors
medicine.disease_cause
Paraganglioma
Humans
Medicine
Endocrine system
Paraganglioma, Extra-Adrenal
Mutation
biology
business.industry
Succinate dehydrogenase
Neural crest
Syndrome
Middle Aged
medicine.disease
Surgery
Succinate Dehydrogenase
biology.protein
business
Subjects
Details
- ISSN :
- 00040010
- Volume :
- 147
- Database :
- OpenAIRE
- Journal :
- Archives of Surgery
- Accession number :
- edsair.doi.dedup.....147b87bbea5e7a58e765a71bdb2980f8
- Full Text :
- https://doi.org/10.1001/archsurg.2011.552