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Surgical Management of the Succinate Dehydrogenase–Associated Familial Paraganglioma Syndromes

Authors :
Pierre F. Saldinger
Andrei Cocieru
Source :
Archives of Surgery. 147:89
Publication Year :
2012
Publisher :
American Medical Association (AMA), 2012.

Abstract

Paragangliomas are rare neuroendocrine tumors arising from the neural crest cells in the extra-adrenal location. Paragangliomas can be sporadic or associated with a range of endocrine and genetic syndromes in 25% to 30% of all cases. Specifically, succinate dehydrogenase gene mutations are involved in the development of paraganglioma syndromes type 1 through type 4. In this article, we will describe 2 cases of succinate dehydrogenase-associated familial paraganglioma syndrome and provide a review of the existing literature on the condition's etiologic factors, diagnosis, and management.

Details

ISSN :
00040010
Volume :
147
Database :
OpenAIRE
Journal :
Archives of Surgery
Accession number :
edsair.doi.dedup.....147b87bbea5e7a58e765a71bdb2980f8
Full Text :
https://doi.org/10.1001/archsurg.2011.552