Back to Search
Start Over
The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients
- Source :
- Renal Failure
- Publication Year :
- 2016
- Publisher :
- Taylor & Francis, 2016.
-
Abstract
- Background: There is limited information about oxidative stress and inflammation on the mortality of Chinese hemodialysis (HD) patients. Subjects and methods: A total of 177 HD patients and 35 healthy controls were enrolled. Their demographic information, clinical characteristics, oxidant and inflammation markers were compared. Multivariate Cox regression analysis was used to assess the risk factors for mortality. Results: Twenty-seven (15.3%) HD patients died during the one-year follow-up. The mean age, age ≥70 years, serum level of cardiac troponin T (cTnT), malondialdehyde (MDA) > 5 nmol/L, as well as CRP >10 mg/L and the level of interleukin (IL)-6 were significantly different between the nonsurvival and survival HD patients. Multivariate Cox's regression analysis identified age, age ≥70 years, cTnT, and IL-6 were independent predictors of mortality in HD patients. Conclusions: Age, age ≥70 years, cTnT, and IL-6 were independent predictors of mortality in Chinese HD patients. Elevated IL-6 level, instead of MDA, was predictive of poor outcome in Chinese hemodialysis patients.
- Subjects :
- Male
medicine.medical_treatment
030232 urology & nephrology
030204 cardiovascular system & hematology
Critical Care and Intensive Care Medicine
medicine.disease_cause
Gastroenterology
chemistry.chemical_compound
End-stage renal disease
0302 clinical medicine
Troponin complex
Risk Factors
Malondialdehyde
oxidative stress
Prospective Studies
hemodialysis
Age Factors
Interleukin
General Medicine
Middle Aged
Prognosis
C-Reactive Protein
Nephrology
Female
Hemodialysis
medicine.symptom
medicine.medical_specialty
China
Inflammation
End stage renal disease
03 medical and health sciences
Troponin T
Predictive Value of Tests
Renal Dialysis
Internal medicine
medicine
Humans
Aged
business.industry
Proportional hazards model
Interleukin-6
mortality
Surgery
chemistry
Clinical Study
Kidney Failure, Chronic
business
Oxidative stress
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 15256049 and 0886022X
- Volume :
- 39
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Renal Failure
- Accession number :
- edsair.doi.dedup.....1479f4b1a1aa1096f5d232014b29ded6