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Normal levels of soluble E-selectin, soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) decrease with age
- Publication Year :
- 1996
- Publisher :
- Blackwell Science Inc, 1996.
-
Abstract
- SUMMARY sE-selectin, sICAM-1, sVCAM-1 and von Willebrand factor (vWF) were assayed in 238 samples in a longitudinal study of 81 normal children from 9.5 to 15.5 years old. Multilevel modelling was used to quantify changes with age. sE-selectin, sICAM-1 and sVCAM-1 all fell significantly over the age range (by 17%, 16%, and 10%, respectively). In contrast, levels of vWF were not age-dependent. Our findings highlight the need for age-matched controls when studying cell surface adhesion molecules in disease groups, and may imply developmental changes in expression of these molecules and their shedding from the cell surface.
- Subjects :
- Male
Aging
Adolescent
Immunology
Cell
Intercellular Adhesion Molecule-1
Vascular Cell Adhesion Molecule-1
Soluble E-Selectin
Von Willebrand factor
Reference Values
E-selectin
von Willebrand Factor
medicine
Immunology and Allergy
Humans
Prospective Studies
Child
biology
Cell adhesion molecule
Chemistry
Adhesion
Original Articles
medicine.anatomical_structure
biology.protein
Female
E-Selectin
Soluble Vascular Cell Adhesion Molecule 1
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....1470d568175952d9f5fe133d1971b0a6