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Dietary treatment of gluten ataxia
- Source :
- Journal of neurology, neurosurgery, and psychiatry. 74(9)
- Publication Year :
- 2003
-
Abstract
- Background: Gluten ataxia is an immune mediated disease, part of the spectrum of gluten sensitivity, and accounts for up to 40% of cases of idiopathic sporadic ataxia. No systematic study of the effect of gluten-free diet on gluten ataxia has ever been undertaken. Objective: To study the effect of gluten-free diet on patients presenting with ataxia caused by gluten sensitivity. Methods: 43 patients with gluten ataxia were studied. All were offered a gluten-free diet and monitored every six months. All patients underwent a battery of tests to assess their ataxia at baseline and after one year on diet. Twenty six patients (treatment group) adhered to the gluten-free diet and had evidence of elimination of antigliadin antibodies by one year. Fourteen patients refused the diet (control group). Three patients had persistently raised antigliadin antibodies despite adherence to the diet and were therefore excluded from the analysis. Results: After one year there was improvement in ataxia reflected in all of the ataxia tests in the treatment group. This was significant when compared with the control group. The diet associated improvement was apparent irrespective of the presence of an enteropathy. Conclusions: Gluten ataxia responds to a strict gluten-free diet even in the absence of an enteropathy. The diagnosis of gluten ataxia is vital as it is one of the very few treatable causes of sporadic ataxia.
- Subjects :
- Adult
Male
Paper
medicine.medical_specialty
congenital, hereditary, and neonatal diseases and abnormalities
Ataxia
Glutens
Diet therapy
Neurological disorder
Gastroenterology
digestive system
Central nervous system disease
Immunopathology
Internal medicine
medicine
Humans
Enteropathy
Aged
chemistry.chemical_classification
Aged, 80 and over
biology
business.industry
nutritional and metabolic diseases
Middle Aged
medicine.disease
Gluten
digestive system diseases
Psychiatry and Mental health
Treatment Outcome
chemistry
Immunology
Antibody Formation
biology.protein
Patient Compliance
Surgery
Female
Neurology (clinical)
medicine.symptom
Gliadin
business
Food Hypersensitivity
Subjects
Details
- ISSN :
- 00223050
- Volume :
- 74
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of neurology, neurosurgery, and psychiatry
- Accession number :
- edsair.doi.dedup.....146777f71d32da841c95f756abb597eb