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Indomethacin produces gastric antral ulcers in the refed rat
- Source :
- Gastroenterology. 81:719-725
- Publication Year :
- 1981
- Publisher :
- Elsevier BV, 1981.
-
Abstract
- Indomethacin produces gastric corpus erosions in the fasted rat and small intestinal ulcers in the conventionally fed rat. We found that in rats fed chow pellets for 1 h after a 24-h fast, indomethacin given within 2 h after refeeding produced lesions in the gastric antrum, primarily along the lesser curvature, and also in the small intestine. The antral lesions reached a maximum size in 6–10 h, penetrated the muscularis mucosae within 3 days, and did not diminish for at least 7 days. The formation of the antral ulcer was prevented by prostaglandins or adrenalectomy, but was not affected by cimetidine, atropine, and/or vagotomy. In contrast, the gastric corpus erosions produced by indomethacin in the fasted rat were prevented by antisecretory drugs or vagotomy, and were aggravated by adrenalectomy. It is concluded that: (a) the chronic antral ulcers produced by indomethacin in the refed rat mimic human gastric ulcer with regard to location and histology; and (b) the mechanism of antral ulcer formation is different from corpus erosion formation, in that it was resistant to antisecretory drugs and vagotomy and was prevented by adrenalectomy. This experimental ulcer model could prove useful for studies of the etiology and therapy of gastric ulcer disease.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Muscularis mucosae
medicine.medical_treatment
Indomethacin
Vagotomy
Gastroenterology
Internal medicine
Pyloric Antrum
Animals
Medicine
Stomach Ulcer
Cimetidine
Antrum
Aspirin
Hepatology
business.industry
Adrenalectomy
digestive, oral, and skin physiology
Fasting
Curvatures of the stomach
digestive system diseases
Small intestine
Rats
Intestines
Atropine
medicine.anatomical_structure
Phenylbutazone
Prostaglandins
business
medicine.drug
Subjects
Details
- ISSN :
- 00165085
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Gastroenterology
- Accession number :
- edsair.doi.dedup.....145e85f6cdcb584dfb3f5dbcb2857abe
- Full Text :
- https://doi.org/10.1016/0016-5085(81)90497-2