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Indomethacin produces gastric antral ulcers in the refed rat

Authors :
Yoshitaka Maki
Hiroshi Satoh
Ikuko Inada
Takeo Hirata
Source :
Gastroenterology. 81:719-725
Publication Year :
1981
Publisher :
Elsevier BV, 1981.

Abstract

Indomethacin produces gastric corpus erosions in the fasted rat and small intestinal ulcers in the conventionally fed rat. We found that in rats fed chow pellets for 1 h after a 24-h fast, indomethacin given within 2 h after refeeding produced lesions in the gastric antrum, primarily along the lesser curvature, and also in the small intestine. The antral lesions reached a maximum size in 6–10 h, penetrated the muscularis mucosae within 3 days, and did not diminish for at least 7 days. The formation of the antral ulcer was prevented by prostaglandins or adrenalectomy, but was not affected by cimetidine, atropine, and/or vagotomy. In contrast, the gastric corpus erosions produced by indomethacin in the fasted rat were prevented by antisecretory drugs or vagotomy, and were aggravated by adrenalectomy. It is concluded that: (a) the chronic antral ulcers produced by indomethacin in the refed rat mimic human gastric ulcer with regard to location and histology; and (b) the mechanism of antral ulcer formation is different from corpus erosion formation, in that it was resistant to antisecretory drugs and vagotomy and was prevented by adrenalectomy. This experimental ulcer model could prove useful for studies of the etiology and therapy of gastric ulcer disease.

Details

ISSN :
00165085
Volume :
81
Database :
OpenAIRE
Journal :
Gastroenterology
Accession number :
edsair.doi.dedup.....145e85f6cdcb584dfb3f5dbcb2857abe
Full Text :
https://doi.org/10.1016/0016-5085(81)90497-2