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Molecular classification improves risk assessment in adult BCR-ABL1–negative B-ALL
- Source :
- Blood
- Publication Year :
- 2021
- Publisher :
- American Society of Hematology, 2021.
-
Abstract
- Genomic classification has improved risk assignment of pediatric, but not adult B-lineage acute lymphoblastic leukemia (B-ALL). The international UKALLXII/ECOG-ACRIN E2993 (#NCT00002514) trial accrued 1229 adolescent/adult patients with BCR-ABL1− B-ALL (aged 14 to 65 years). Although 93% of patients achieved remission, 41% relapsed at a median of 13 months (range, 28 days to 12 years). Five-year overall survival (OS) was 42% (95% confidence interval, 39, 44). Transcriptome sequencing, gene expression profiling, cytogenetics, and fusion polymerase chain reaction enabled genomic subtyping of 282 patient samples, of which 264 were eligible for trial, accounting for 64.5% of E2993 patients. Among patients with outcome data, 29.5% with favorable outcomes (5-year OS 65% to 80%) were deemed standard risk (DUX4-rearranged [9.2%], ETV6-RUNX1/-like [2.3%], TCF3-PBX1 [6.9%], PAX5 P80R [4.1%], high-hyperdiploid [6.9%]); 50.2% had high-risk genotypes with 5-year OS of 0% to 27% (Ph-like [21.2%], KMT2A-AFF1 [12%], low-hypodiploid/near-haploid [14.3%], BCL2/MYC-rearranged [2.8%]); 20.3% had intermediate-risk genotypes with 5-year OS of 33% to 45% (PAX5alt [12.4%], ZNF384/-like [5.1%], MEF2D-rearranged [2.8%]). IKZF1 alterations occurred in 86% of Ph-like, and TP53 mutations in patients who were low-hypodiploid (54%) and BCL2/MYC-rearranged (33%) but were not independently associated with outcome. Of patients considered high risk based on presenting age and white blood cell count, 40% harbored subtype-defining genetic alterations associated with standard- or intermediate-risk outcomes. We identified distinct immunophenotypic features for DUX4-rearranged, PAX5 P80R, ZNF384-R/-like, and Ph-like genotypes. These data in a large adult B-ALL cohort treated with a non–risk-adapted approach on a single trial show the prognostic importance of genomic analyses, which may translate into future therapeutic benefits.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Immunology
Fusion Proteins, bcr-abl
BCR/ABL1 Negative
Risk Assessment
Biochemistry
Gastroenterology
Young Adult
Molecular classification
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
White blood cell
Internal medicine
Genotype
medicine
Humans
Proto-Oncogene Proteins c-abl
Gene Rearrangement
Lymphoid Neoplasia
business.industry
Cytogenetics
Cell Biology
Hematology
Middle Aged
Prognosis
Confidence interval
medicine.anatomical_structure
Mutation
Proto-Oncogene Proteins c-bcr
Cohort
Female
Transcriptome
Risk assessment
business
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 138
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....145a0e4ab14f15e512f922bf0f8e822e