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Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer
- Source :
- Radiation Oncology Journal
- Publication Year :
- 2016
- Publisher :
- The Korean Society for Radiation Oncology, 2016.
-
Abstract
- PURPOSE A prospective phase II trial was conducted to evaluate the effectiveness and toxicity of regional hyperthermia and whole liver irradiation (WLI) for numerous chemorefractory liver metastases from colorectal cancer. MATERIALS AND METHODS Enrolled patients had numerous chemorefractory hepatic metastases from colorectal cancer. Five sessions of hyperthermia and seven fractions of 3-gray WLI were planned. Health-related quality of life (HRQoL) was determined using the Korean version of the European Organization for Research and Treatment of Cancer quality of life questionnaire C-30 and the Functional Assessment of Cancer Therapy-Hepatobiliary version 4.0. Objective and pain response was evaluated. RESULTS A total of 12 patients consented to the study and the 10 who received WLI and hyperthermia were analyzed. WLI was completed as planned in nine patients and hyperthermia in eight. Pain response was partial in four patients and stable in four. Partial objective response was achieved in three patients (30.0%) and stable disease was seen in four patients at the 1-month follow-up. One patient died 1 month after treatment because of respiratory failure related to pleural metastasis progression. Other grade III or higher toxicities were detected in three patients; however, all severe toxicities were related to disease progression rather than treatment. No significant difference in HRQoL was noted at the time of assessment for patients who were available for questionnaires. CONCLUSION Combined WLI and hyperthermia were well tolerated without severe treatment-related toxicity with a promising response from numerous chemorefractory hepatic metastases from colorectal cancer.
- Subjects :
- Oncology
Hyperthermia
Quality of life
medicine.medical_specialty
Pathology
Colorectal cancer
medicine.medical_treatment
Pain
Colorectal neoplasms
03 medical and health sciences
0302 clinical medicine
Stable Disease
Internal medicine
Medicine
Radiology, Nuclear Medicine and imaging
030212 general & internal medicine
Clinical Investigation
Induced hyperthermia
Radiotherapy
business.industry
Cancer
medicine.disease
Radiation therapy
Respiratory failure
030220 oncology & carcinogenesis
Toxicity
Original Article
business
Subjects
Details
- Language :
- English
- ISSN :
- 22343164 and 22341900
- Volume :
- 34
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Radiation Oncology Journal
- Accession number :
- edsair.doi.dedup.....1437fad72a687dac732bd824db43749d