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Prediction of Time to Castration-Resistant Prostate Cancer Using Bone Scan Index in Men with Metastatic Hormone-Sensitive Prostate Cancer
- Source :
- Urologia internationalis. 99(4)
- Publication Year :
- 2017
-
Abstract
- Introduction: We evaluated bone scan index (BSI) as a predictive biomarker for time to castration-resistant prostate cancer (CRPC) in patients with metastatic hormone-sensitive prostate cancer (mHSPC). Materials and Methods: We identified 85 consecutive mHSPC patients treated with first-line androgen deprivation therapy. We analyzed the correlations between time to CRPC and clinicopathological characteristics, including age, prostate-specific antigen (PSA) level, Gleason score, clinical TNM stage, hemoglobin, lactate dehydrogenase, C-reactive protein, and BSI. Results: The median BSI was 2.7%. Progression to CRPC occurred in 55 (64.7%) patients and the median time to CRPC was 12.9 months. In multivariate analysis, 3 significant risk factors for time to CRPC were identified: age (>73 vs. ≤73 years; hazard ratio [HR] 0.53), p = 0.038, PSA level (>270 vs. ≤270 ng/mL; HR 0.53, p = 0.038), and BSI (>2.7 vs. ≤2.7%; HR 2.97, p < 0.001). Conclusion: Age, PSA level, and BSI were found to be significant predictive factors for time to CRPC in patients with mHSPC.
- Subjects :
- Oncology
Male
Multivariate analysis
Time Factors
Kaplan-Meier Estimate
urologic and male genital diseases
030218 nuclear medicine & medical imaging
Androgen deprivation therapy
Prostate cancer
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Medicine
Stage (cooking)
Aged, 80 and over
Hazard ratio
Age Factors
Middle Aged
Prostatic Neoplasms, Castration-Resistant
030220 oncology & carcinogenesis
Disease Progression
Radiographic Image Interpretation, Computer-Assisted
Kallikreins
PCA3
Adult
medicine.medical_specialty
Neoplasms, Hormone-Dependent
Urology
Bone Neoplasms
Adenocarcinoma
03 medical and health sciences
Predictive Value of Tests
Internal medicine
Lactate dehydrogenase
Humans
Aged
Proportional Hazards Models
Retrospective Studies
business.industry
Prostatic Neoplasms
Androgen Antagonists
Prostate-Specific Antigen
medicine.disease
Bone scan index
chemistry
Drug Resistance, Neoplasm
Multivariate Analysis
Neural Networks, Computer
business
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 14230399
- Volume :
- 99
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Urologia internationalis
- Accession number :
- edsair.doi.dedup.....142f3c4d83a4d6275298e7bccc11e472