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Functional polymorphisms of the mineralocorticoid receptor geneNR3C2are associated with diminished memory decline: Results from a longitudinal general‐population study
- Source :
- Molecular Genetics & Genomic Medicine, Vol 8, Iss 9, Pp n/a-n/a (2020), Molecular Genetics & Genomic Medicine, Molecular genetics & genomic medicine 8(9), e1345 (2020). doi:10.1002/mgg3.1345
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Background The mineralocorticoid receptor (MR) in the brain has a key role in the regulation of the central stress response and is associated with memory performance. We investigated whether the genetic polymorphisms rs5522 and rs2070951 of NR3C2 showed main and interactive effects with childhood trauma on memory decline. Methods Declarative memory was longitudinally assessed in 1,318 participants from the community‐dwelling Study of Health in Pomerania using the Verbal Learning and Memory Test (VLMT). In a subsample of 377 participants aged 60 and older, the Mini‐Mental Status Examination (MMSE) was additionally applied. Mean follow‐up time for the VLMT and MMSE were 6.4 and 10.7 years, respectively. Results Homozygous carriers of the G allele of rs2070951 (p<br />The mineralocorticoidreceptor has a central role in the brains stress response. In this longitudinal general population study, we investigated whether rs5522 and rs2070951 of the MR gene are associated with memory performance. Using two different measures for memory performance, we found that these single nucleotide polymorphisms were associated with diminished declarative memory decline.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
lcsh:QH426-470
rs2070951
030105 genetics & heredity
Verbal learning
Polymorphism, Single Nucleotide
03 medical and health sciences
genetics [Receptors, Mineralocorticoid]
Memory
Internal medicine
Genotype
Genetics
Humans
Medicine
Cognitive Dysfunction
ddc:610
Cognitive decline
Allele
Molecular Biology
Genetics (clinical)
Aged
mineralocorticoid receptor
Recall
business.industry
Haplotype
genetics [Cognitive Dysfunction]
rs5522
Original Articles
NR3C2 gene
Middle Aged
cognitive decline
lcsh:Genetics
Receptors, Mineralocorticoid
030104 developmental biology
Endocrinology
Haplotypes
Study of Health in Pomerania
Population study
Original Article
Female
business
Subjects
Details
- ISSN :
- 23249269
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Molecular Genetics & Genomic Medicine
- Accession number :
- edsair.doi.dedup.....142834cad776dffb658e00aa40052a81