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Response of the human hepatic tissue cultures Hep-G2 and WRL-68 to cocaine

Authors :
P.M. Falk
R.T. Sabater
D.D. Carballo
Source :
Journal of pharmacological and toxicological methods. 33(2)
Publication Year :
1995

Abstract

The hydrolytic metabolism of cocaine into benzoylecgonine, ecgonine methyl ester, and ecgonine was studied in the human hepatoma cell line Hep-G2 and in the nontumorigenic fetal hepatic cell line WRL-68. Also, the toxicological response of these cells to cocaine was compared to previously published results obtained with perfused liver cells and in vivo systems. Our experiments indicated that Hep-G2 appear to have similar metabolic and toxicological patterns to in vivo and perfused cell systems. The WRL-68 tissue culture system was found to be less similar. These results suggest Hep-G2 cells can be utilized to study cocaine metabolism and toxicology, and possibly in studies involving other xenobiotic compounds.

Details

ISSN :
10568719
Volume :
33
Issue :
2
Database :
OpenAIRE
Journal :
Journal of pharmacological and toxicological methods
Accession number :
edsair.doi.dedup.....1423032c49956152481fd2bdc8f84e71