Supplementary Figure 4 from Characterization of a New Class of Androgen Receptor Antagonists with Potential Therapeutic Application in Advanced Prostate Cancer

PDF file, 2136K, (A) Effect of VPC-3022 on AR activity in HeLa-AR cells in the presence of cyclohexamide. HeLa-AR cells were treated with serially-diluted concentrations of VPC-3022 (0 - 100 ?M) with or without 10 ?M of cyclohexamide for 8 hours, and then lysed with passive lysis buffer. (B) AR degradation caused by VPC-3031 and VPC-3041 in HeLa-AR cells. HeLa-AR cells were treated by VPC-3031 and VPC-3041 at different concentrations in the presence of 0.1 nM R1881.