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Hypoxia Modulates Regenerative Potential of Fetal Stem Cells
- Source :
- Applied Sciences, Vol 12, Iss 363, p 363 (2022), Applied Sciences; Volume 12; Issue 1; Pages: 363
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Adult mesenchymal stem cells (MSCs) are prone to senescence, which limits the scope of their use in tissue engineering and regeneration and increases the likelihood of post-implantation failure. As a robust alternative cell source, fetal stem cells can prevent an immune reaction and senescence. However, few studies use this cell type. In this study, we sought to characterize fetal cells’ regenerative potential in hypoxic conditions. Specifically, we examined whether hypoxic exposure during the expansion and differentiation phases would affect human fetal nucleus pulposus cell (NPC) and fetal synovium-derived stem cell (SDSC) plasticity and three-lineage differentiation potential. We concluded that fetal NPCs represent the most promising cell source for chondrogenic differentiation, as they are more responsive and display stronger phenotypic stability, particularly when expanded and differentiated in hypoxic conditions. Fetal SDSCs have less potential for chondrogenic differentiation compared to their adult counterpart. This study also indicated that fetal SDSCs exhibit a discrepancy in adipogenic and osteogenic differentiation in response to hypoxia.
- Subjects :
- Fluid Flow and Transfer Processes
fetal stem cell
hypoxia
differentiation
fetal nucleus pulposus cell
fetal synovium-derived stem cell
Technology
QH301-705.5
Process Chemistry and Technology
Physics
QC1-999
General Engineering
Engineering (General). Civil engineering (General)
Computer Science Applications
Chemistry
General Materials Science
TA1-2040
Biology (General)
Instrumentation
QD1-999
Subjects
Details
- Language :
- English
- ISSN :
- 20763417
- Volume :
- 12
- Issue :
- 363
- Database :
- OpenAIRE
- Journal :
- Applied Sciences
- Accession number :
- edsair.doi.dedup.....13fed6fa564a0539d4bb9a07f1bd89a8