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Bromodomain-dependent stage-specific male genome programming by Brdt: Brdt: a master regulator of spermatogenesis
- Source :
- EMBO Journal, EMBO Journal, 2012, 31 (19), pp.3809-3820. ⟨10.1038/emboj.2012.233⟩, EMBO Journal, EMBO Press, 2012, 31 (19), pp.3809-3820. ⟨10.1038/emboj.2012.233⟩
- Publication Year :
- 2012
- Publisher :
- HAL CCSD, 2012.
-
Abstract
- International audience; Male germ cell differentiation is a highly regulated multistep process initiated by the commitment of progenitor cells into meiosis and characterized by major chromatin reorganizations in haploid spermatids. We report here that a single member of the double bromodomain BET factors, Brdt, is a master regulator of both meiotic divisions and post-meiotic genome repackaging. Upon its activation at the onset of meiosis, Brdt drives and determines the developmental timing of a testis-specific gene expression program. In meiotic and post-meiotic cells, Brdt initiates a genuine histone acetylation-guided programming of the genome by activating essential genes and repressing a ‘progenitor cells’ gene expression program. At post-meiotic stages, a global chromatin hyperacetylation gives the signal for Brdt's first bromodomain to direct the genome-wide replacement of histones by transition proteins. Brdt is therefore a unique and essential regulator of male germ cell differentiation, which, by using various domains in a developmentally controlled manner, first drives a specific spermatogenic gene expression program, and later controls the tight packaging of the male genome.
- Subjects :
- Genetics
0303 health sciences
BRD4
General Immunology and Microbiology
biology
General Neuroscience
[SDV]Life Sciences [q-bio]
Genome
General Biochemistry, Genetics and Molecular Biology
Chromatin
Bromodomain
Gene expression profiling
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Histone
030220 oncology & carcinogenesis
medicine
biology.protein
Molecular Biology
Gene
Germ cell
030304 developmental biology
Subjects
Details
- Language :
- English
- ISSN :
- 02614189 and 14602075
- Database :
- OpenAIRE
- Journal :
- EMBO Journal, EMBO Journal, 2012, 31 (19), pp.3809-3820. ⟨10.1038/emboj.2012.233⟩, EMBO Journal, EMBO Press, 2012, 31 (19), pp.3809-3820. ⟨10.1038/emboj.2012.233⟩
- Accession number :
- edsair.doi.dedup.....13fda4c486b3440baf9dc45083c2bdac