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Hyper-response to Novelty Increases c-Fos Expression in the Hippocampus and Prefrontal Cortex in a Rat Model of Schizophrenia
- Source :
- Neurochemical Research. 43:441-448
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Schizophrenia is a debilitating disorder that may have a neurodevelopmental origin. For this reason, animal models based on neonatal insults or manipulations have been extensively used to demonstrate schizophrenia-related behaviors. Among those, the neonatal ventral hippocampus lesion (nVHL) is largely used as a model of schizophrenia-related behavior as it mimics behavioral and neurochemical abnormalities often seen in schizophrenic patients including hyperlocomotion in a novel environment. To investigate the neuroanatomical basis of coding novelty in the nVHL rat, we assessed the behavioral locomotor activity paradigm in a novel environment and measured expression of c-Fos, a marker of neural activation, in brain regions involved in the process of coding novelty or locomotion. Upon reaching adulthood, nVHL rats showed hyperlocomotion in the novel environment paradigm. Moreover, in nVHL rats the expression of c-Fos was greater in the prefrontal cortex (PFC) and CA1 region of the dorsal hippocampus compared to sham rats. Whereas similar expression of c-Fos was observed in the basolateral amygdala, nucleus accumbens and dentate gyrus region of hippocampus of nVHL and sham rats. These results suggest that the nVHL disrupts the neural activity in the PFC and CA1 region of hippocampus in the process of coding novelty in the rat.
- Subjects :
- 0301 basic medicine
Prefrontal Cortex
Hippocampus
Biology
Nucleus accumbens
Biochemistry
c-Fos
Nucleus Accumbens
Rats, Sprague-Dawley
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Neurochemical
medicine
Animals
Prefrontal cortex
Neurons
Novelty
General Medicine
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Animals, Newborn
nervous system
Schizophrenia
biology.protein
Female
Proto-Oncogene Proteins c-fos
Neuroscience
030217 neurology & neurosurgery
Basolateral amygdala
Subjects
Details
- ISSN :
- 15736903 and 03643190
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Neurochemical Research
- Accession number :
- edsair.doi.dedup.....13f89e67f5233be743d789d0b82aaceb