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Frequency-dependent exacerbation of Alzheimer’s disease neuropathophysiology
- Source :
- Scientific Reports, Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group UK, 2019.
-
Abstract
- Neuronal activity patterns are disrupted in neurodegenerative disorders, including Alzheimer’s disease (AD). One example is disruption of corticothalamic slow oscillations responsible for sleep-dependent memory consolidation. Slow waves are periodic oscillations in neuronal activity occurring at frequencies of
- Subjects :
- 0301 basic medicine
Genetically modified mouse
Amyloid
Amyloid beta
lcsh:Medicine
Stimulation
Mice, Transgenic
Plaque, Amyloid
Neurotransmission
Optogenetics
Neural circuits
Synaptic Transmission
Article
03 medical and health sciences
Mice
0302 clinical medicine
Alzheimer Disease
Image Processing, Computer-Assisted
Premovement neuronal activity
Animals
lcsh:Science
Neurons
Neurotransmitter Agents
Multidisciplinary
Amyloid beta-Peptides
biology
Chemistry
lcsh:R
Alzheimer's disease
Molecular Imaging
Disease Models, Animal
030104 developmental biology
Microscopy, Fluorescence, Multiphoton
biology.protein
Disease Progression
lcsh:Q
Memory consolidation
Calcium
Disease Susceptibility
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....13eae9d98a97750a69369efdee7ae715