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Effect of Ginseng Extracts on the Improvement of Osteopathic and Arthritis Symptoms in Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
- Source :
- Nutrients, Volume 13, Issue 10, Nutrients, Vol 13, Iss 3352, p 3352 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Ginsenosides are active compounds that are beneficial to bone metabolism and have anti-osteoporosis properties. However, very few clinical investigations have investigated the effect of ginseng extract (GE) on bone metabolism. This study aims to determine the effect of GE on improving bone metabolism and arthritis symptoms in postmenopausal women with osteopenia. A 12-week randomized, double-blind, placebo-controlled clinical trial was conducted. A total of 90 subjects were randomly divided into a placebo group, GE 1 g group, and GE 3 g group for 12 weeks based on the random 1:1:1 assignment to these three groups. The primary outcome is represented by bone metabolism indices consisting of serum osteocalcin (OC), urine deoxypyridinoline (DPD), and DPD/OC measurements. Secondary outcomes were serum CTX, NTX, Ca, P, BsALP, P1NP, OC/CTX ratio, and WOMAC index. The GE 3 g group had a significantly increased serum OC concentration. Similarly, the GE 3 g group showed a significant decrease in the DPD/OC ratio, representing bone resorption and bone formation. Moreover, among all the groups, the GE 3 g group demonstrated appreciable improvements in the WOMAC index scores. In women with osteopenia, intake of 3 g of GE per day over 12 weeks notably improved the knee arthritis symptoms with improvements in the OC concentration and ratios of bone formation indices like DPD/OC.
- Subjects :
- Knee arthritis
Deoxypyridinoline
medicine.medical_specialty
WOMAC
arthritis symptoms
Osteocalcin
Panax
Phenylenediamines
Placebo
Gastroenterology
Article
Bone resorption
Bone remodeling
Placebos
Eating
Ginseng
chemistry.chemical_compound
Double-Blind Method
Internal medicine
Humans
Medicine
TX341-641
Exercise
Nutrition and Dietetics
Nutrition. Foods and food supply
Plant Extracts
business.industry
Arthritis
Middle Aged
medicine.disease
Osteopenia
Bone Diseases, Metabolic
Treatment Outcome
osteopenia
chemistry
Female
Bone Remodeling
bone metabolism
business
ginseng extract
Biomarkers
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....13e32cac9c078e3980652cc06ccaf7a2
- Full Text :
- https://doi.org/10.3390/nu13103352