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Improvement in mood, oxidative stress, fatigue, and insomnia following supplementary management with RobuvitĀ®

Authors :
Maria Rosaria Cesarone
Mark Dugall
Beatrice Feragalli
Roberta Luzzi
Aristide Saggino
Morio Hosoi
Gianni Belcaro
Umberto Cornelli
Source :
Journal of neurosurgical sciences. 62(4)
Publication Year :
2018

Abstract

BACKGROUND Oxidative stress (OS) plays a substantial role in inflammatory and neurodegenerative diseases, causing cellular damage and mitochondrial dysfunction. OS also contributes to aging and severe neural disorders such as Alzheimer's and Parkinson's diseases. Previous registries have documented a reduction in OS levels with Robuvit® (Horphag Research, Ltd.), an extract from wood of the French oak (Quercus robur) that provides a decrease of OS as well as relief from chronic fatigue syndrome. The aim of the present registry was to investigate the influence of Robuvit® on a group of subjects presenting with mood disorders, oxidative stress, fatigue, and insomnia. METHODS Forty patients were recruited from a selection of patients with high OS levels as assessed with the d-ROMs test. Twenty-two subjects formed the control group following the standard management plan. The remaining 18 subjects formed the Robuvit® supplementation group. They received three capsules of Robuvit® 100 mg per day, for 8 weeks. RESULTS Tolerability to the supplementation with Robuvit® was overall good, and no safety concerns were raised. Mood tests showed a significant general improvement in 13 out of 16 items of the BMIS (P

Details

ISSN :
18271855
Volume :
62
Issue :
4
Database :
OpenAIRE
Journal :
Journal of neurosurgical sciences
Accession number :
edsair.doi.dedup.....13d1414a337d4a5f7292ae8035726244