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Pre-transplant depression decreased overall survival of patients receiving allogeneic hematopoietic stem cell transplantation: a nationwide cohort study
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- Studies investigating association of depression with overall survival (OS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) yielded conflicting results. A nationwide cohort study, which included all adult patients [n = 7,170; depression group, 13.3% (N = 956); non-depression group, 86.7% (N = 6,214)] who received allo-HSCT from 2002 to 2018 in South Korea, analyzed risk of pre-transplant depression in OS of allo-HSCT. Subjects were followed from the day they received allo-HSCT, to occurrence of death, or last follow-up day (December 31, 2018). Median age at allo-HSCT for depression and non-depression groups were 50 and 45 (p p p p = 0.04), and to having both depression and anxiety disorder (aHR = 1.202, CI: 1.038–1.393, p = 0.014) groups. Pre-transplant anxiety (anxiety only) did not have significant influence in OS. Additional medical and psychiatric care might be necessary in patients who experienced depression, especially with anxiety, before allo-HSCT.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Patients
lcsh:Medicine
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
Republic of Korea
medicine
Humans
Transplantation, Homologous
Signs and symptoms
lcsh:Science
Survival rate
Depression (differential diagnoses)
Retrospective Studies
Multidisciplinary
business.industry
Depression
Hazard ratio
lcsh:R
Hematopoietic Stem Cell Transplantation
Retrospective cohort study
Middle Aged
medicine.disease
Anxiety Disorders
Transplantation
Survival Rate
030104 developmental biology
surgical procedures, operative
Neurology
Oncology
Risk factors
030220 oncology & carcinogenesis
Anxiety
Female
lcsh:Q
medicine.symptom
business
Anxiety disorder
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....13d0ba20ab5f2e6322df3ca5bf523a34