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Corticosterone response to gestational stress and postpartum memory function in mice
- Source :
- PLoS ONE, Vol 12, Iss 7, p e0180306 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- Maternal stress is a common adversity during pregnancy. Gestational corticosterone alternations are thought to contribute to the etiology of postpartum behavioral disturbances. However, the impact of stress during pregnancy, in particular noise exposure, on gestational corticosterone fluctuations and spatial cognition in postpartum mice has not been fully understood yet. We hypothesized that noise exposure during pregnancy negatively affects gestational corticosterone levels and postpartum memory function in the dams similar to the physical stressors. Pregnant C57BL/6 mice were randomly assigned to either one of two stress conditions or a control condition. The noise stress (NS) was induced by presenting a loud intermittent 3000 Hz frequency on gestational days (GDs) 12, 14, and 16 for 24 hours, whereas the physical stress (PS) consisted of restraint and exposure to an elevated platform on GDs 12-16. Plasma corticosterone level was collected on GDs 11 and 17, and Morris water task (MWT) was carried out 30 days after parturition. Compared to the control group, the level of corticosterone in the stressed groups was significantly increased on GD17 relative to GD11. Significantly longer swim time and lower swim speed were observed in both stressed groups relative to the control group. Probe time was significantly shorter in the NS group than the other groups. The delta corticosterone level was significantly correlated with the swim time as well as the probe time in the three groups. Given the results, the adverse effects of gestational noise exposure on the hypothalamic pituitary-adrenal (HPA) axis activation and postpartum spatial learning and memory function were as large as/ or a bit stronger than the physical stresses. The findings suggest the significance of conservation against loud noise exposure in daily living, as well as need to further notice to the different aspects of gestational stress in mothers' behavior like offspring.
- Subjects :
- Male
0301 basic medicine
Physiology
Maternal Health
Social Sciences
lcsh:Medicine
chemistry.chemical_compound
Learning and Memory
Cognition
0302 clinical medicine
Pregnancy
Corticosterone
Blood plasma
Medicine and Health Sciences
Psychology
Medicine
lcsh:Science
Animal Management
Cognitive Impairment
Multidisciplinary
Cognitive Neurology
Postpartum Period
Obstetrics and Gynecology
Agriculture
Body Fluids
Blood
Neurology
Gestation
Female
Anatomy
Research Article
medicine.medical_specialty
Offspring
Cognitive Neuroscience
Psychological Stress
Blood Plasma
03 medical and health sciences
Maternal stress
Memory
Internal medicine
Mental Health and Psychiatry
Animals
Maze Learning
Swimming
Animal Performance
Biological Locomotion
business.industry
Stressor
lcsh:R
Biology and Life Sciences
medicine.disease
Mice, Inbred C57BL
030104 developmental biology
Endocrinology
chemistry
Women's Health
Cognitive Science
lcsh:Q
business
Stress, Psychological
030217 neurology & neurosurgery
Postpartum period
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....13cbb211d4984a475aa5052a7010850c