Back to Search
Start Over
Acute Encephalitis Syndrome in Gorakhpur, Uttar Pradesh, 2016
- Source :
- Pediatric Infectious Disease Journal. 37:1101-1106
- Publication Year :
- 2018
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2018.
-
Abstract
- Seasonal outbreaks of acute encephalitis syndrome (AES) with high fatality have been occurring in Gorakhpur, Uttar Pradesh, India, for several years. We conducted investigations during the 2016 outbreak to identify the etiology.We included 407 hospitalized AES patients with cerebrospinal fluid pleocytosis (5 cells/mm) in our study. These patients were clinically examined; their blood and cerebrospinal fluid samples were collected and investigated for scrub typhus (ST), Japanese encephalitis virus (JEV), dengue virus and spotted fever group of Rickettsia by serology and/or polymerase chain reaction.Of the 407 AES patients, 266 (65.4%), 42 (10.3%) and 29 (7.1%) were diagnosed to have ST, JEV and dengue infection, respectively. Four patients were diagnosed to have spotted fever group of Rickettsia infection. A significantly higher proportion of ST patients with AES had hepatomegaly, splenomegaly and facial edema. The common hematologic and biochemical abnormalities among ST-positive patients include thrombocytopenia, raised liver enzymes and bilirubin levels. The case fatality ratio was significantly higher among ST-negative AES patients (36.2% vs. 15.2%; P0.05).ST accounted for approximately two third of the AES case-patients. Efforts are required to identify the etiology of AES case-patients who are negative for ST, JEV and dengue fever.
- Subjects :
- Male
0301 basic medicine
Microbiology (medical)
Pediatrics
medicine.medical_specialty
030106 microbiology
India
Polymerase Chain Reaction
Disease Outbreaks
Dengue
03 medical and health sciences
parasitic diseases
Acute Febrile Encephalopathy
Humans
Medicine
Child
Encephalitis, Japanese
business.industry
Infant
Outbreak
Rickettsia Infections
medicine.disease
Hospitalization
Infectious Diseases
Immunoglobulin M
Scrub Typhus
Child, Preschool
Pediatrics, Perinatology and Child Health
Acute encephalitis
Female
Seasons
business
Uttar pradesh
Encephalitis
Subjects
Details
- ISSN :
- 08913668
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Pediatric Infectious Disease Journal
- Accession number :
- edsair.doi.dedup.....13c799c5cc9fd23851f845ffd417b4ea