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Neovascular Prostate-Specific Membrane Antigen Expression Is Associated with Improved Overall Survival under Palliative Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma
- Source :
- BioMed Research International, Vol 2017 (2017), BioMed Research International
- Publication Year :
- 2017
- Publisher :
- Hindawi Limited, 2017.
-
Abstract
- Aims. Expression of PSMA (prostate-specific membrane antigen) has been demonstrated in various cancers, including pancreatic ductal adenocarcinoma (PDAC). However, PSMA expression in PDAC-associated neovasculature has so far not been systematically analyzed.Methods and Results. We analyzed PSMA expression in 81 PDAC tissue samples from 61 patients. Microvessel density (MVD) was assessed by software-based image analysis and showed a mean MVD of 63.7 microvessels/0.785 mm2. PSMA was practically absent in tumor tissue (5.3%) and PDAC cell lines (0/7) but could be detected in tumor-associated neovasculature in 53.2% of cases. There was no association between neovascular PSMA expression and clinicopathological tumor characteristics. Samples with PSMA+ neovasculature showed increased MVD; however, this result was not statistically significant (p>0.05). Presence of PSMA+ neovessels correlated with overall survival under palliative chemotherapy (894 versus 400 days; HR 0.42; 95% CI: 0.12 to 0.87;p<0.05).Conclusion. PSMA expression in tumor-associated neovasculature is a common feature and associated with improved overall survival under palliative chemotherapy in PDAC. Our results point towards a possible association between PSMA expression and response to therapy which might be based on enhanced intratumoral bioavailability of systemic chemotherapy.
- Subjects :
- Adult
Glutamate Carboxypeptidase II
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Palliative care
Article Subject
CD34
lcsh:Medicine
Adenocarcinoma
urologic and male genital diseases
Disease-Free Survival
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Glutamate carboxypeptidase II
Carcinoma
Humans
Aged
Aged, 80 and over
Neovascularization, Pathologic
General Immunology and Microbiology
biology
business.industry
Palliative Care
lcsh:R
Cancer
General Medicine
Middle Aged
medicine.disease
digestive system diseases
Gene Expression Regulation, Neoplastic
030104 developmental biology
Cell culture
030220 oncology & carcinogenesis
Antigens, Surface
Microvessels
biology.protein
Female
Antibody
business
Research Article
Carcinoma, Pancreatic Ductal
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2017
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....13bbd2a126ab6d5178df59f2b7fe2b53