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A phase I/II study of combined cisplatin and hyperthermia treatment for refractory malignancy
- Source :
- International Journal of Hyperthermia. 5:13-21
- Publication Year :
- 1989
- Publisher :
- Informa UK Limited, 1989.
-
Abstract
- Research in animal and human cell cultures has shown that some chemotherapeutic agents, cisplatin in particular, have cytotoxicity that is significantly potentiated at elevated temperatures. Concurrent administration of systemic cisplatin and local hyperthermia in human patients has not been previously reported. A phase I/II study was undertaken to assess the systemic and local toxicities and activity of concurrently administered local hyperthermia and systemic cisplatin in human tumours. Nine patients with histologically proven malignant tumours have been treated from March 1985 to July 1987. Their histologies were: breast, four; SCC of head and neck, two; SCC of skin, one; malignant melanoma, one; synovial cell sarcoma, one. Once-weekly hyperthermia was administered for 60 min by external microwave devices in an attempt to achieve minimum intratumoral temperatures of 42 degrees C. Plastic catheters were placed intratumorally under CT guidance for thermometry purposes. Cisplatin 40-60 mg/m2 was given over 60 min when steady-state heating was achieved. A total of 44 treatments are available for analysis. All nine patients had minimum intratumoral temperatures below the desired goal of 42 degrees C, and only two patients achieved average intratumoral temperatures of 42 degrees C or greater. Two of the responding patients sustained significant thermal injury consisting of blistering and necrosis. Three patients required transfusion and delay of weekly treatment because of anaemia and leukopenia. Four patients had partial response (PR) and one patient had minor response (MR) within the heated treatment volume. Three of these five patients experienced significant subjective palliation. This combination of treatment modalities can be delivered safely.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Adult
Male
Hyperthermia
Cancer Research
Pathology
medicine.medical_specialty
Hot Temperature
Physiology
medicine.medical_treatment
Malignancy
Refractory
Neoplasms
Physiology (medical)
medicine
Humans
Radiology, Nuclear Medicine and imaging
Cytotoxicity
Aged
Cisplatin
Clinical Trials as Topic
Chemotherapy
Radiation
business.industry
Melanoma
Hyperthermia Treatment
Middle Aged
medicine.disease
Combined Modality Therapy
Oncology
Cancer research
Female
Sarcoma
Burns
business
medicine.drug
Subjects
Details
- ISSN :
- 14645157 and 02656736
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- International Journal of Hyperthermia
- Accession number :
- edsair.doi.dedup.....13b819a57311da35041bd00e312cec10