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Age-Associated Abnormalities of Water Homeostasis
- Source :
- Endocrinology and Metabolism Clinics of North America. 52:277-293
- Publication Year :
- 2023
- Publisher :
- Elsevier BV, 2023.
-
Abstract
- Findley first proposed the presence of age-related dysfunction of the hypothalamic-neurohypophyseal-renal axis more than 60 years ago. More sophisticated studies have since corroborated his findings. As a result, it is now clear that multiple abnormalities in water homeostasis occur commonly with aging, and that the elderly are uniquely susceptible to disorders of body volume and osmolality. This article summarizes the distinct points along the hypothalamic-neurohypophyseal-renal axis where these changes have been characterized, as well as the clinical significance of these changes, with special attention to effects on cognition, gait instability, osteoporosis, fractures, and morbidity and mortality.
- Subjects :
- Risk
medicine.medical_specialty
Aging
Hypothalamo-Hypophyseal System
Endocrinology, Diabetes and Metabolism
Osteoporosis
Water-Electrolyte Imbalance
Physiology
Kidney
Severity of Illness Index
Article
Inappropriate ADH Syndrome
Kidney Concentrating Ability
Endocrinology
Pituitary Gland, Posterior
Internal medicine
Severity of illness
medicine
Animals
Humans
Clinical significance
Renal Insufficiency
Multiple abnormalities
business.industry
Cognition
medicine.disease
Arginine Vasopressin
Hypernatremia
Hyponatremia
business
Homeostasis
Subjects
Details
- ISSN :
- 08898529
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Endocrinology and Metabolism Clinics of North America
- Accession number :
- edsair.doi.dedup.....13aa78b388c4a1ec1c192d36a6d3e888