Back to Search
Start Over
The worldwide seroprevalence of DENV, CHIKV and ZIKV infection: A systematic review and meta-analysis
- Source :
- PLoS Neglected Tropical Diseases, PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009337 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science, 2021.
-
Abstract
- Background As the three major arthropod-borne viruses, dengue virus (DENV), chikungunya virus (CHIKV), and zika virus (ZIKV) are posing a growing threat to global public health and socioeconomic development. Our study aimed to systematically review the global seroprevalences of these arboviruses from existing publications. Methods Articles published between Jan 01, 2000 and Dec 31, 2019 in the databases of Embase, Pubmed and Web of Science were searched and collected. Countries or areas with known local presence of Aedes vector mosquitoes were included. Random effects model was utilized to estimate the pooled seroprevalences and the proportion of inapparent infection. Results Out of 1375, a total of 133 articles involving 176,001 subjects were included for our analysis. The pooled seroprevalences of DENV, CHIKV and ZIKV were 38%, 25% and 18%, respectively; and their corresponding proportions of inapparent infections were 80%, 40% and 50%. The South-East Asia Region had the highest seroprevalences of DENV and CHIKV, while the Region of the Americas had the highest seroprevalence of ZIKV. The seroprevalences of DENV and CHIKV were similar when comparing developed and developing countries, urban and rural areas, or among different populations. In addition, we observed a decreased global seroprevalences in the new decade (2010–2019) comparing to the decade before (2000–2009) for CHIKV. For ZIKV, the positive rates tested with the nucleic acid detection method were lower than those tested with the antibody detection method. Lastly, numerous cases of dual seropositivity for CHIKV and DENV were reported. Conclusions Our results revealed a varied prevalence of arbovirus infections in different geographical regions and countries, and the inapparent infection accounted an unneglected portion of infections that requires more attention. This study will shed lights on our understanding of the true burden of arbovirus infections and promote appropriate vaccination in the future.<br />Author summary DENV, CHIKV, and ZIKV infections are the three major neglected tropical diseases continually posing threats to the public health and the socioeconomic development in recent decades. Given a high fraction of inapparent infections of these viruses, it is necessary to obtain informative knowledge of the seroepidemiology of DENV, CHIKV, and ZIKV worldwide, so as to estimate the true burden of these diseases and evaluate effects on vaccine efficacy and uptake. Given the fact that the reported infection rates may vary greatly due to the measurement, criteria of inclusion, and etc, a systematic review with meta-analysis is essential to collect and summarize the seroepidemiologic evidence of these arboviruses. In this study, the geographical distributions of DENV, CHIKV, and ZIKV and the proportions of their inapparent infections were analyzed, which revealed an overall high disease burden to the world, especially in specific regions. The epidemiological features of these arboviruses were also characterized via comparisons made in different countries/areas, populations, and time periods. In addition, evidence on the co-infection of DENV and CHIKV was assessed.
- Subjects :
- RNA viruses
Viral Diseases
Physiology
viruses
RC955-962
Dengue virus
medicine.disease_cause
Pathology and Laboratory Medicine
Global Health
Biochemistry
Zika virus
Dengue
Medical Conditions
Mathematical and Statistical Techniques
Aedes
Seroepidemiologic Studies
Arctic medicine. Tropical medicine
Immune Physiology
Medicine and Health Sciences
Chikungunya
Chikungunya Virus
Immune System Proteins
biology
Zika Virus Infection
Statistics
virus diseases
Metaanalysis
Vaccination
Infectious Diseases
Medical Microbiology
Arboviral Infections
Viral Pathogens
Viruses
Physical Sciences
Public aspects of medicine
RA1-1270
Pathogens
Research Article
Neglected Tropical Diseases
Arbovirus Infections
Alphaviruses
Immunology
Mosquito Vectors
Research and Analysis Methods
Microbiology
Antibodies
Togaviruses
medicine
Seroprevalence
Animals
Humans
Statistical Methods
Microbial Pathogens
Biology and life sciences
Flaviviruses
Public Health, Environmental and Occupational Health
Organisms
Chikungunya Infection
Proteins
Zika Virus
Dengue Virus
biology.organism_classification
Tropical Diseases
Virology
Vector (epidemiology)
Chikungunya Fever
Arboviruses
Mathematics
Subjects
Details
- Language :
- English
- ISSN :
- 19352735 and 19352727
- Volume :
- 15
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- PLoS Neglected Tropical Diseases
- Accession number :
- edsair.doi.dedup.....139a190cddb0ca2ca87e908711844387