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Identification of the novel Np17 oncogene in human leukemia
- Source :
- Aging (Albany NY)
- Publication Year :
- 2020
-
Abstract
- We previously defined the HERV-K Np9 as a viral oncogene. Here we report the discovery of a novel oncogene, Np17, which is homologous to the viral Np9 gene and predominantly present in Hominoidea. Np17 is located on chromosome 8, consists of 7 exons, and encodes a 16.8kDa nuclear protein with149 amino-acid residue. Functionally, knockdown of Np17 induced growth inhibition of leukemia cells, whereas enforced expression of Np17 promoted growth of leukemia cells in vitro and in vivo. In human leukemia, Np17 was detected in 59.65% (34/57) of acute myeloid leukemia (AML) patients examined and associated with refractory/relapsed AML. Mechanistically, Np17 decreased p53 levels and its mechanism might be involved in recruiting nuclear MDM2 to p53 for ubiquitin-mediated degradation. These findings reveal that Np17 is a novel oncogene associated with refractory/relapsed leukemia.
- Subjects :
- Aging
THP-1 Cells
Viral Oncogene
HL-60 Cells
Mice, SCID
Np9
Biology
chemistry.chemical_compound
Mice, Inbred NOD
oncogene
hemic and lymphatic diseases
medicine
Animals
Humans
Nuclear protein
Cell Proliferation
Oncogene Proteins
Gene knockdown
P53
Leukemia
Oncogene
Gene Expression Regulation, Leukemic
Np17
Ubiquitination
Myeloid leukemia
Proto-Oncogene Proteins c-mdm2
Cell Biology
medicine.disease
Neoplasm Proteins
chemistry
Case-Control Studies
Proteolysis
Cancer research
biology.protein
Mdm2
Female
Growth inhibition
Tumor Suppressor Protein p53
K562 Cells
Signal Transduction
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 12
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....13967a17598f778354c79aa1d6676a53