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Erratum. Genetic and nongenetic factors for contralateral progression of unilateral moyamoya disease: the first report from the SUPRA Japan Study Group

Authors :
Akio Koizumi
Yoshio Araki
Yohei Mineharu
Hitoshi Hasegawa
Susumu Miyamoto
Tomohito Hishikawa
Yasushi Takagi
Satoshi Kuroda
Takeshi Funaki
Takaaki Morimoto
Jun Takahashi
Kiyohiro Houkin
Source :
Journal of Neurosurgery. 136:1207
Publication Year :
2022
Publisher :
Journal of Neurosurgery Publishing Group (JNSPG), 2022.

Abstract

OBJECTIVE Although many studies have analyzed risk factors for contralateral progression in unilateral moyamoya disease, they have not been fully elucidated. The aim of this study was to examine whether genetic factors as well as nongenetic factors are involved in the contralateral progression. METHODS The authors performed a multicenter cohort study in which 93 cases with unilateral moyamoya disease were retrospectively reviewed. The demographic features, RNF213 R4810K mutation, lifestyle factors such as smoking and drinking, past medical history, and angiographic findings were analyzed. A Cox proportional hazards model was used to find risk factors for contralateral progression. RESULTS Contralateral progression was observed in 24.7% of cases during a mean follow-up period of 72.2 months. Clinical characteristics were not significantly different between 67 patients with the R4810K mutation and those without it. Cox regression analysis showed that the R4810K mutation (hazard ratio [HR] 4.64, p = 0.044), childhood onset (HR 7.21, p < 0.001), male sex (HR 2.85, p = 0.023), and daily alcohol drinking (HR 4.25, p = 0.034) were independent risk factors for contralateral progression. CONCLUSIONS These results indicate that both genetic and nongenetic factors are associated with contralateral progression of unilateral moyamoya disease. The findings would serve to help us better understand the pathophysiology of moyamoya disease and to manage patients more appropriately.

Details

ISSN :
19330693 and 00223085
Volume :
136
Database :
OpenAIRE
Journal :
Journal of Neurosurgery
Accession number :
edsair.doi.dedup.....1393fe754c85a9dd91b75dbbca62d6e1
Full Text :
https://doi.org/10.3171/2020.10.jns203913a