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Seroprevalence of viral infectious diseases and associated factors in Korean patients with inflammatory bowel diseases

Authors :
Hee Seung Hong
Seung-Jae Myung
Suk-Kyun Yang
Jeong-Sik Byeon
Sung Wook Hwang
Jiwon Jung
Dong-Hoon Yang
Byong Duk Ye
Hwa Jung Kim
Sang Hyoung Park
Source :
The Korean Journal of Internal Medicine, Vol 37, Iss 1, Pp 73-84 (2022), The Korean Journal of Internal Medicine
Publication Year :
2022
Publisher :
The Korean Association of Internal Medicine, 2022.

Abstract

Background/Aims: Data on the immunoprotective status against measles, mumps, rubella, varicella zoster virus (VZV), hepatitis A virus (HAV), and Epstein-Barr virus (EBV) infection in patients with inflammatory bowel disease (IBD) are still lacking. Therefore, we investigated the seropositivity rates for viral infectious diseases and the associated factors in Korean patients with IBD.Methods: In this retrospective cohort study, serum immunoglobulin G antibody positivity rates against measles virus, mumps virus, rubella virus, VZV, HAV, and EBV viral capsid antigen (VCA) were measured in patients with Crohn’s disease or ulcerative colitis (UC) who first visited the IBD clinic. Seropositivity rates and their associated factors were analyzed.Results: Between January 2016 and December 2018, 263 patients were enrolled (male, 167 [67.3%]; UC, 134 [50.9%]). The median age at serological test was 30 years (interquartile range, 22 to 46). The seropositivity rates were 84.0%, 85.2%, 66.5%, 87.4%, 50.0%, and 93.7% for measles, mumps, rubella, VZV, HAV, and EBV, respectively. Younger age at serological test was associated with seronegative status for measles (adjusted odds ratio [aOR], 0.92; 95% confidence interval [CI], 0.88 to 0.96), VZV (aOR, 0.83; 95% CI, 0.74 to 0.93), and HAV (aOR, 0.93; 95% CI, 0.91 to 0.95). Furthermore, IBD type-UC was associated with seronegative status against VZV (aOR, 0.33; 95% CI, 0.11 to 0.99).Conclusions: Seropositivity rates for common viral infectious diseases in Korean patients with IBD were similar to those of the general population. In the younger age group, protective immunity against measles, VZV, and HAV is required, with proper vaccination, as necessary.

Details

Language :
English
ISSN :
20056648 and 12263303
Volume :
37
Issue :
1
Database :
OpenAIRE
Journal :
The Korean Journal of Internal Medicine
Accession number :
edsair.doi.dedup.....1381b67ae0cc5452f22116a70717e78e