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Seroprevalence of viral infectious diseases and associated factors in Korean patients with inflammatory bowel diseases
- Source :
- The Korean Journal of Internal Medicine, Vol 37, Iss 1, Pp 73-84 (2022), The Korean Journal of Internal Medicine
- Publication Year :
- 2022
- Publisher :
- The Korean Association of Internal Medicine, 2022.
-
Abstract
- Background/Aims: Data on the immunoprotective status against measles, mumps, rubella, varicella zoster virus (VZV), hepatitis A virus (HAV), and Epstein-Barr virus (EBV) infection in patients with inflammatory bowel disease (IBD) are still lacking. Therefore, we investigated the seropositivity rates for viral infectious diseases and the associated factors in Korean patients with IBD.Methods: In this retrospective cohort study, serum immunoglobulin G antibody positivity rates against measles virus, mumps virus, rubella virus, VZV, HAV, and EBV viral capsid antigen (VCA) were measured in patients with Crohn’s disease or ulcerative colitis (UC) who first visited the IBD clinic. Seropositivity rates and their associated factors were analyzed.Results: Between January 2016 and December 2018, 263 patients were enrolled (male, 167 [67.3%]; UC, 134 [50.9%]). The median age at serological test was 30 years (interquartile range, 22 to 46). The seropositivity rates were 84.0%, 85.2%, 66.5%, 87.4%, 50.0%, and 93.7% for measles, mumps, rubella, VZV, HAV, and EBV, respectively. Younger age at serological test was associated with seronegative status for measles (adjusted odds ratio [aOR], 0.92; 95% confidence interval [CI], 0.88 to 0.96), VZV (aOR, 0.83; 95% CI, 0.74 to 0.93), and HAV (aOR, 0.93; 95% CI, 0.91 to 0.95). Furthermore, IBD type-UC was associated with seronegative status against VZV (aOR, 0.33; 95% CI, 0.11 to 0.99).Conclusions: Seropositivity rates for common viral infectious diseases in Korean patients with IBD were similar to those of the general population. In the younger age group, protective immunity against measles, VZV, and HAV is required, with proper vaccination, as necessary.
- Subjects :
- Male
medicine.medical_specialty
Epstein-Barr Virus Infections
Herpesvirus 4, Human
viruses
Population
seroepidemiologic studies
Mumps virus
medicine.disease_cause
Antibodies, Viral
Measles
Rubella
Communicable Diseases
inflammatory bowel diseases
Measles virus
Internal medicine
Republic of Korea
medicine
Humans
education
Mumps
Retrospective Studies
education.field_of_study
biology
business.industry
Vaccination
Varicella zoster virus
Gastroenterology
virus diseases
Rubella virus
medicine.disease
biology.organism_classification
digestive system diseases
Medicine
Original Article
business
Subjects
Details
- Language :
- English
- ISSN :
- 20056648 and 12263303
- Volume :
- 37
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Korean Journal of Internal Medicine
- Accession number :
- edsair.doi.dedup.....1381b67ae0cc5452f22116a70717e78e