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Quality of life of survivors 1 year after the diagnosis of diffuse large B-cell lymphoma: a LYSA study
- Source :
- Annals of Hematology, Annals of Hematology, 2022, 101 (2), pp.317-332. ⟨10.1007/s00277-021-04689-4⟩
- Publication Year :
- 2021
-
Abstract
- Health-related quality of life (HRQoL) is a multidimensional concept including physical, emotional, social, and cognitive functions, disease symptoms, and side effects of treatment. Differences in HRQoL due to gender, existence of comorbidities, and number of chemotherapy cycles are little explored in diffuse large B-cell lymphoma (DLBCL) survivors. Our objective was to investigate whether differences in HRQoL in function of these factors exist 1 year after the diagnosis of DLBCL. One hundred and one patients, enrolled in the RT3 (Real-Time Tailored Therapy) Study, answered self-administrated European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), EORTC High-Grade Non-Hodgkin Lymphoma (NHL-HG29), Hospital Anxiety and Depression Scale (HADS), Post Traumatic Growth Inventory (PTGI), and Multidimensional Fatigue Inventory (MFI) questionnaires. Adjusted means of scores were calculated in multivariate linear regression models. Fifty-seven survivors (mean age of 58.5 years) answered all questionnaires. Women have significantly higher scores of posttraumatic growth and lower physical functioning than men (P < 0.04). Survivors with comorbidities have increased physical fatigue and symptom burden, increased emotional impact, mental fatigue and depression, and reduced physical functioning and global health status (all P < 0.05). A greater number of cycles of chemotherapy increase the level of symptoms (pain, neuropathy, and dyspnoea; P < 0.05). The various aspects related to HRQoL should be discussed with DLBCL patients and investigated, with the aim of developing strategies to ensure appropriate psychosocial and supportive care and to improve the HRQoL in these patients. Supplementary Information The online version contains supplementary material available at 10.1007/s00277-021-04689-4.
- Subjects :
- Adult
Male
medicine.medical_specialty
Lymphoma
Health Status
[SDV.CAN]Life Sciences [q-bio]/Cancer
Disease
Hospital Anxiety and Depression Scale
Comorbidities
Young Adult
[SDV.CAN] Life Sciences [q-bio]/Cancer
Quality of life
Cancer Survivors
Internal medicine
Bayesian multivariate linear regression
Surveys and Questionnaires
medicine
Chemotherapy
Humans
Survivors
Depression (differential diagnoses)
Aged
Aged, 80 and over
Posttraumatic growth
business.industry
Hematology
General Medicine
Middle Aged
medicine.disease
humanities
Quality of Life
Original Article
Female
Lymphoma, Large B-Cell, Diffuse
business
Diffuse large B-cell lymphoma
Psychosocial
Subjects
Details
- ISSN :
- 14320584 and 09395555
- Volume :
- 101
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Annals of hematology
- Accession number :
- edsair.doi.dedup.....137ca73de0d5d67d081ca162da1ea4da