Antioxidant and cytotoxic studies for kaempferol, quercetin and isoquercitrin

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:26:15Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:47:27Z : No. of bitstreams: 1 2-s2.0-84859494413.pdf: 157067 bytes, checksum: d670e87351aa7fd9ddc270543eedb525 (MD5) Made available in DSpace on 2014-05-27T11:26:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-12-01 The aim of the present study was to investigate a cytotoxic oxidative cell stress related and the antioxidant profile of kaempferol, quercetin, and isoquercitrin. The flavonol compounds were able to act as scavengers of superoxide anion (but not hydrogen peroxide), hypochlorous acid, chloramine and nitric oxide. Although flavonoids are widely described as antioxidants and this activity is generally related to beneficial effects on human health, here we show important cytotoxic actions of three well known flavonoids. They were able to promote hemolysis which one was exacerbated on the presence of hypochlorous acid but not by AAPH radical. Therefore, despite they expected scavenger action over free radicals an oxidants, these compounds could be very lesive to living organisms by acting over erythrocytes and maybe other cellular types. UEPG Paraná State University of Ponta Grossa Graduate Program in Pharmaceutical Sciences, General Carlos Cavalcanti Avenue, 4748, Uvaranas, Ponta Grossa-PR, 84030-900 Biochemistry and Tecnology Chemistry Department Chemistry Institute São Paulo State University, Araraquara-SP Organic Chemistry Department Chemistry Institute São Paulo State University, Araraquara-SP UNICENTRO Pharmacy Department, Guarapuava-PR IFG Goiás Federal Institute, Formosa-GO Biochemistry and Tecnology Chemistry Department Chemistry Institute São Paulo State University, Araraquara-SP Organic Chemistry Department Chemistry Institute São Paulo State University, Araraquara-SP