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Latest knowledge about changes in the proteome in microgravity

Authors :
Herbert Schulz
Sebastian M. Strauch
Peter Richter
Markus Wehland
Marcus Krüger
Jayashree Sahana
Thomas J. Corydon
Petra Wise
Ronni Baran
Michael Lebert
Daniela Grimm
Source :
Schulz, H, Strauch, S M, Richter, P, Wehland, M, Krüger, M, Sahana, J, Corydon, T J, Wise, P, Baran, R, Lebert, M & Grimm, D 2022, ' Latest knowledge about changes in the proteome in microgravity ', Expert Review of Proteomics, vol. 19, no. 1, pp. 43-59 . https://doi.org/10.1080/14789450.2022.2030711
Publication Year :
2022

Abstract

INTRODUCTION: : A long-term stay of humans in space causes a large number of well-known health problems and changes in protists and plants. Deep space exploration will increase the time humans or rodents will spend in microgravity (µg). Moreover, they are exposed to cosmic radiation, hypodynamia, and isolation. OMICS investigations will increase our knowledge of the underlying mechanisms of µg-induced alterations in vivo and in vitro.AREAS COVERED: : We summarize the findings over the recent 3 years on µg-induced changes in the proteome of protists, plants, rodent and human cells. Considering the thematic orientation of microgravity-related publications in that time frame, we focus on medicine-associated findings such as the µg-induced antibiotic resistance of bacteria, the myocardial consequences of µg-induced calpain activation and the role of MMP13 in osteoarthritis. All these point to the fact that µg is an extreme stressor that could not be evolutionarily addressed on Earth.EXPERT COMMENTARY: : In conclusion, when interpreting µg-experiments, the direct, mostly unspecific stress response, must be distinguished from specific µg-effects. For this reason, recent studies often do not consider single protein findings but place them in the context of protein-protein interactions. This enables an estimation of functional relationships, especially if these are supported by epigenetic and transcriptional data (multi-omics).

Details

Language :
English
Database :
OpenAIRE
Journal :
Schulz, H, Strauch, S M, Richter, P, Wehland, M, Krüger, M, Sahana, J, Corydon, T J, Wise, P, Baran, R, Lebert, M & Grimm, D 2022, ' Latest knowledge about changes in the proteome in microgravity ', Expert Review of Proteomics, vol. 19, no. 1, pp. 43-59 . https://doi.org/10.1080/14789450.2022.2030711
Accession number :
edsair.doi.dedup.....13781c0088111990fb138c918512f836
Full Text :
https://doi.org/10.1080/14789450.2022.2030711