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Shigella dysenteriae infection activates proinflammatory response through β-catenin/NF-κB signaling pathway
- Source :
- PLoS ONE, PLoS ONE, Vol 12, Iss 4, p e0174943 (2017)
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- Shigella dysenteriae (S.dysenteriae) the causative agent of bacillary dysentery invades the human colonic epithelium resulting in severe intestinal inflammatory response and epithelial destruction. However, the mechanism by which S.dysenteriae infection regulates proinflammatory cytokines during intestinal inflammation is still obscure. In this study, we evaluated whether the interaction of β-catenin and NF-κB regulates proinflammatory cytokines TNF-α and IL-8 by modulating GSK-3β activity during S.dysenteriae infection in rat ileal loop model. Here we demonstrated that S.dysenteriae infection stimulate β-catenin degradation which in turn decreased the association between NF-κB and β-catenin. Also, we showed that S.dysenteriae infection increased GSK-3β kinase activity which in turn phosphorylates β-catenin for its degradation by ubiquitination and upregulates IL-8 through NF-κB activation thereby leading to inflammation. Thus these findings revealed the role of β-catenin/ NF-κB and GSK-3β in modulating the inflammatory response during bacterial infection and also showed that β-catenin acts as a critical regulator of inflammation.
- Subjects :
- Bacterial Diseases
0301 basic medicine
Physiology
lcsh:Medicine
Pathology and Laboratory Medicine
Biochemistry
0302 clinical medicine
Immune Physiology
Medicine and Health Sciences
Post-Translational Modification
Phosphorylation
lcsh:Science
Immune Response
beta Catenin
Innate Immune System
Multidisciplinary
Bacterial Gastroenteritis
biology
Chemistry
NF-kappa B
Gastroenteritis
Bacterial Pathogens
Infectious Diseases
Shigellosis
Medical Microbiology
030220 oncology & carcinogenesis
Cytokines
Anatomy
Pathogens
Inflammation Mediators
medicine.symptom
Signal transduction
Research Article
Neglected Tropical Diseases
Signal Transduction
Shigella dysenteriae
Beta-catenin
Immunology
Inflammation
Gastroenterology and Hepatology
Research and Analysis Methods
Microbiology
Proinflammatory cytokine
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
medicine
Animals
Humans
Animal Models of Disease
Kinase activity
Microbial Pathogens
Dysentery, Bacillary
Bacteria
lcsh:R
Inflammatory Bowel Disease
Organisms
Biology and Life Sciences
Proteins
Molecular Development
Tropical Diseases
biology.organism_classification
NFKB1
Rats
Gastrointestinal Tract
Animal Models of Infection
030104 developmental biology
Immune System
Catenin
Animal Studies
biology.protein
lcsh:Q
Shigella
Digestive System
Developmental Biology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....1359d7fec06acf54ab5b23e1251de11c