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Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China
- Source :
- PLoS Neglected Tropical Diseases, PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008975 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science, 2021.
-
Abstract
- Wuhan City (WH) in China was the first place to report COVID-19 in the world and the outbreak of COVID-19 was controlled in March of 2020 in WH. It is unclear what percentage of people were infected with SARS-CoV-2 and what percentage of population is carriers of SARS-CoV-2 in WH. We retrospectively analyzed the SARS-CoV-2 IgG and IgM antibody positive rates in 63,107 healthy individuals from WH and other places of China using commercial colloidal gold detection kits from March 6 to May 3, 2020. Statistical approaches were utilized to explore the difference and correlation for the seropositive rate of IgG and IgM antibody on the basis of sex, age group, geographic region and detection date. The total IgG and IgM antibody positive rate of SARS-CoV-2 was 1.68% (186/11,086) in WH, 0.59% (226/38,171) in Hubei Province without Wuhan (HB), and 0.38% (53/13,850) in the nation except for Hubei Province (CN), respectively. The IgM positive rate was 0.46% (51/11,086) in WH, 0.13% (51/38,171) in HB, and 0.07% (10/13,850) in CN. The incidence of IgM positive rates in healthy individuals increased from March 6 to May 3, 2020 in WH. Female and older age had a higher probability of becoming infected than males (OR = 1.34; 95% CI: 1.08–1.65) or younger age (OR = 2.25; 95% CI: 1.06–4.78). The seroprevalence of SARS-CoV-2 was relatively low in WH and other places of China, but it is significantly high in WH than other places of China; a large amount of asymptomatic carriers of SARS-CoV-2 existed after elimination of clinical cases of COVID-19 in Wuhan City. Therefore, SARS-CoV-2 may exist in a population without clinical cases for a long period.<br />Author summary Our study has investigated 63,107 healthy individuals from Wuhan City and other places in China to analyze the seroprevalence of SARS-CoV-2, which was correlated with geographic region, age, sex and the detection time. The seroprevalence of SARS-CoV-2 was relatively low in WH (1.68%, 186/11,086) and other places of China (0.38%, 53/13,850), but the seroprevalence is significantly higher in Wuhan City than other cities and other places in China. Moreover, the antibody positive rate was higher in regions closer to Wuhan City. The results of binary logistic regression model showed that the higher seroprevalence was observed among older individuals and females had a higher probability of being infected than males.
- Subjects :
- RNA viruses
Male
Viral Diseases
Time Factors
Coronaviruses
Physiology
RC955-962
030204 cardiovascular system & hematology
Antibodies, Viral
Biochemistry
Geographical Locations
0302 clinical medicine
Medical Conditions
Seroepidemiologic Studies
Arctic medicine. Tropical medicine
Immune Physiology
Nucleic Acids
Epidemiology
030212 general & internal medicine
Young adult
Pathology and laboratory medicine
Virus Testing
education.field_of_study
Immune System Proteins
Geography
Incidence (epidemiology)
Age Factors
Medical microbiology
Middle Aged
Infectious Diseases
Viruses
Carrier State
Female
Public aspects of medicine
RA1-1270
SARS CoV 2
Pathogens
Research Article
Adult
medicine.medical_specialty
China
Asia
SARS coronavirus
Adolescent
Population
Immunology
Microbiology
Antibodies
03 medical and health sciences
Young Adult
Sex Factors
Diagnostic Medicine
medicine
Seroprevalence
Humans
education
Retrospective Studies
Medicine and health sciences
Biology and life sciences
business.industry
SARS-CoV-2
Public Health, Environmental and Occupational Health
Organisms
Viral pathogens
Outbreak
Proteins
COVID-19
Covid 19
Microbial pathogens
Regional Geography
Logistic Models
Immunoglobulin M
Age Groups
Immunoglobulin G
People and Places
Earth Sciences
Population Groupings
business
Asymptomatic carrier
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 19352735 and 19352727
- Volume :
- 15
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- PLoS Neglected Tropical Diseases
- Accession number :
- edsair.doi.dedup.....134c105cf9be6c8ab6dffa03ceafbda1