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In Situ Stimulated Raman Scattering (SRS) Microscopy Study of the Dissolution of Sustained-Release Implant Formulation
- Source :
- Molecular pharmaceutics. 15(12)
- Publication Year :
- 2018
-
Abstract
- Localized drug delivery systems (DDSs) provide therapeutic levels of drug agent while mitigating side effects of systemic delivery. These systems offer controlled release over extended periods of time making them attractive therapies. Monitoring drug dissolution is vital for developing safe and effective means of drug delivery. Currently, dissolution characterization methods are limited to bulk analysis and cannot provide dissolution kinetics at high spatial resolution. However, dissolution rates of drug particles can be heterogeneous with influences from many factors. Insights into finer spatiotemporal dynamics of single particle dissolution could potentially improve pharmacokinetic modeling of dissolution for future drug development. In this work, we demonstrate high-resolution chemical mapping of entecavir, a hepatitis B antiviral drug, embedded in a slow release poly(d,l-lactic acid) formulation with stimulated Raman scattering (SRS) microscopy. By tracking the volume change of individual micron-sized drug particles within the polymer matrix, we establish an analytical protocol for quantitatively profiling dissolution of single crystalline particles in implant formulations in an in situ manner.
- Subjects :
- 0301 basic medicine
Drug
Chemical imaging
Materials science
Guanine
media_common.quotation_subject
Chemistry, Pharmaceutical
Polyesters
Pharmaceutical Science
Nanotechnology
02 engineering and technology
Spectrum Analysis, Raman
03 medical and health sciences
Drug Discovery
Dissolution testing
Drug/agent
Particle Size
Dissolution
media_common
Drug Implants
Drug Carriers
Microscopy
021001 nanoscience & nanotechnology
Controlled release
Drug Liberation
030104 developmental biology
Drug development
Drug delivery
Molecular Medicine
0210 nano-technology
Subjects
Details
- ISSN :
- 15438392
- Volume :
- 15
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Molecular pharmaceutics
- Accession number :
- edsair.doi.dedup.....134441913e927007e19574f97a61ccd6