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Sleep in ADCY5 -Related Dyskinesia: Prolonged Awakenings Caused by Abnormal Movements
- Source :
- Journal of Clinical Sleep Medicine, Journal of Clinical Sleep Medicine, 2019, 15 (7), pp.1021-1029. ⟨10.5664/jcsm.7886⟩
- Publication Year :
- 2019
- Publisher :
- American Academy of Sleep Medicine (AASM), 2019.
-
Abstract
- STUDY OBJECTIVES: ADCY5 mutations cause early-onset hyperkinetic movement disorders comprising diurnal and nocturnal paroxysmal dyskinesia, and patient-reported sleep fragmentation. We aimed to characterize all movements occurring during sleep and in the transition from sleep to awakening, to ascertain if there is a primary sleep disorder, or if the sleep disturbance is rather a consequence of the dyskinesia. METHODS: Using video polysomnography, we evaluated the nocturnal motor events and abnormal movements in 7 patients with ADCY5-related dyskinesia and compared their sleep measures with those of 14 age- and sex-matched healthy controls. RESULTS: We observed an increased occurrence of abnormal movements during wake periods compared to sleep in patients with ADCY5-related dyskinesia. While asleep, abnormal movements occurred more frequently during stage N2 and REM sleep, in contrast with stage N3 sleep. Abnormal movements were also more frequent during morning awakenings compared to wake periods before falling asleep. The pattern of the nocturnal abnormal movements mirrored those observed during waking hours. Compared to controls, patients with ADCY5-related dyskinesia had lower sleep efficiencies due to prolonged awakenings secondary to the abnormal movements, but no other differences in sleep measures. Notably, sleep onset latency was short and devoid of violent abnormal movements. CONCLUSIONS: In this series of patients with ADCY5-related dyskinesia, nocturnal paroxysmal dyskinesia were not associated with drowsiness or delayed sleep onset, but emerged during nighttime awakenings with subsequent delayed sleep, whereas sleep architecture was normal.
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Movement disorders
genetic structures
Nocturnal
03 medical and health sciences
0302 clinical medicine
Internal medicine
mental disorders
medicine
chorea
sleep
Dystonia
ADCY5
business.industry
Chorea
Paroxysmal dyskinesia
medicine.disease
Sleep in non-human animals
dyskinesia
030228 respiratory system
Neurology
Dyskinesia
Cardiology
dystonia
Neurology (clinical)
medicine.symptom
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15509397 and 15509389
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Sleep Medicine
- Accession number :
- edsair.doi.dedup.....134101aef4cb19e9f4f8be6738ddee93