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Current Understanding of Group A Streptococcal Biofilms
- Source :
- Current Drug Targets
- Publication Year :
- 2019
- Publisher :
- Bentham Science Publishers, 2019.
-
Abstract
- Background:It has been proposed that GAS may form biofilms. Biofilms are microbial communities that aggregate on a surface, and exist within a self-produced matrix of extracellular polymeric substances. Biofilms offer bacteria an increased survival advantage, in which bacteria persist, and resist host immunity and antimicrobial treatment. The biofilm phenotype has long been recognized as a virulence mechanism for many Gram-positive and Gram-negative bacteria, however very little is known about the role of biofilms in GAS pathogenesis.Objective:This review provides an overview of the current knowledge of biofilms in GAS pathogenesis. This review assesses the evidence of GAS biofilm formation, the role of GAS virulence factors in GAS biofilm formation, modelling GAS biofilms, and discusses the polymicrobial nature of biofilms in the oropharynx in relation to GAS.Conclusion:Further study is needed to improve the current understanding of GAS as both a monospecies biofilm, and as a member of a polymicrobial biofilm. Improved modelling of GAS biofilm formation in settings closely mimicking in vivo conditions will ensure that biofilms generated in the lab closely reflect those occurring during clinical infection.
- Subjects :
- 0301 basic medicine
Host immunity
Streptococcus pyogenes
Virulence Factors
030106 microbiology
Clinical Biochemistry
Virulence
Oropharynx
Polymicrobial biofilms
Models, Biological
Article
antibiotics
Microbiology
03 medical and health sciences
Extracellular polymeric substance
Drug Discovery
Drug Resistance, Bacterial
Survival advantage
biofilm modelling
Pharmacology
biology
Chemistry
polymicrobial
Group A Streptococcus
Biofilm
Streptococcus
Gene Expression Regulation, Bacterial
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
Anti-Bacterial Agents
030104 developmental biology
Biofilms
biofilm formation
Molecular Medicine
Bacteria
Subjects
Details
- Language :
- English
- ISSN :
- 18735592 and 13894501
- Volume :
- 20
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Current Drug Targets
- Accession number :
- edsair.doi.dedup.....133f3c80433f069e7e9b4cd0722eeacf