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Effects of annular contraction on anterior leaflet strain using an in vitro simulator with a dynamically contracting mitral annulus
- Source :
- Journal of Biomechanics. 66:51-56
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Using in vitro models, the mechanics as well as surgical techniques for mitral valves (MV) and MV devices can be studied in a more controlled environment with minimal monetary investment and risk. However, these current models rely on certain simplifications, one being that the MV has a static, rigid annulus. In order to study more complex issues of imaging diagnostics and implanted device function, it would be more advantageous to verify their use for a dynamic environment in a dynamic simulator. This study provides the novel design and development of a dynamically contracting annulus (DCA) within an in vitro simulator, and its subsequent use to study MV biomechanics. Experiments were performed to study the ability of the DCA to reproduce the MV leaflet mechanics in vitro, as seen in vivo, as well as investigate how rigid annuloplasties affect MV leaflet mechanics. Experiments used healthy, excised MVs and normal hemodynamics; contractile waveforms were derived from human in vivo data. Stereophotogrammetry and echocardiography were used to measure anterior leaflet strain and the change in MV geometry. In pursuit of the first in vitro MV simulator that more completely represents the dynamic motion of the full valvular apparatus, this study demonstrated the successful operation of a dynamically contracting mitral annulus. It was seen that the diseased contractile state increased anterior leaflet strain compared to the healthy contractile state. In addition, it was also shown in vitro that simulated rigid annuloplasty increased mitral anterior leaflet strain compared to a healthy contraction.
- Subjects :
- Materials science
Contraction (grammar)
Swine
0206 medical engineering
Biomedical Engineering
Biophysics
Environment controlled
02 engineering and technology
030204 cardiovascular system & hematology
Article
03 medical and health sciences
0302 clinical medicine
In vivo
Mitral valve
medicine
Animals
Humans
Orthopedics and Sports Medicine
cardiovascular diseases
Mitral annulus
Implanted device
Simulation
Anterior leaflet
Sheep
Rehabilitation
Biomechanics
Mitral Valve Insufficiency
020601 biomedical engineering
medicine.anatomical_structure
Echocardiography
Photogrammetry
cardiovascular system
Mitral Valve
Subjects
Details
- ISSN :
- 00219290
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Journal of Biomechanics
- Accession number :
- edsair.doi.dedup.....1338348b331219a82a7b90d98ba32844