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'Lupinosis'-like lesions in mice caused by ustiloxin, produced by Ustilaginoieda virens: a morphological study
- Source :
- Natural toxins. 2(1)
- Publication Year :
- 1994
-
Abstract
- A crude toxin, obtained by methanol-extraction of a water extract of false smut balls (INA-KOUJI in Japanese) caused by Ustilaginoidea virens on rice panicles, was injected into mice intraperitoneally. Single injection of 100 or 200 mg/kg body weight of the extract was not lethal but caused acute, occasional necrosis of hepatocytes and renal tubular cells, followed by increased number of mitotic figures with occasional multinuclear giant cells. Erosions and ulceration of the forestomach and atrophy of the thymus were observed a week later. Repeated intraperitoneal injection of the crude toxin at the levels of 12 and 25 mg/kg body weight induced more severe necrosis of the liver and kidneys, with delayed occurrence of mitosis. Forestomach erosion also occurred. Serial injection for 10-12 days of either 3 or 6 mg/kg of the crude extract or 400 micrograms/kg of ustiloxin A, using the purified crystals, caused relatively mild but definite liver and kidney lesions similar to those described above. The lesions in the liver and kidney were quite similar to those observed in lupinosis caused by phomopsin A, a mycotoxin produced by Phomopsis leptostromiformis. Isolation of the toxic substance indicates that the contaminated rice panicles may cause toxicosis of cattle, although no field outbreaks have occurred yet.
- Subjects :
- Male
medicine.medical_specialty
Pathology
Necrosis
medicine.medical_treatment
Intraperitoneal injection
Toxicology
medicine.disease_cause
Kidney
Peptides, Cyclic
chemistry.chemical_compound
Mice
Atrophy
Ustiloxin A
Internal medicine
medicine
Animals
Mycotoxin
Ustilaginales
Mice, Inbred ICR
biology
Toxin
Stomach
Ustilaginoidea virens
Mycotoxicosis
Oryza
Mycotoxins
biology.organism_classification
medicine.disease
Endocrinology
chemistry
Liver
Giant cell
Female
medicine.symptom
Injections, Intraperitoneal
Subjects
Details
- ISSN :
- 10569014
- Volume :
- 2
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Natural toxins
- Accession number :
- edsair.doi.dedup.....1330b697e72e1ee3c1fd73d57f21c874