Supplementary Figures 1 - 3 from Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells

PDF file, 225KB, 1. EGFR ligands induce resistance to ALK inhibitors in a dose dependent manner in H2228 cells 2.H2228 cells were highly sensitive to siRNAs specific for ALK, whereas HGF and/or EGFR ligands (EGF, TGF-α, and HB-EGF) reduced the sensitivity of siRNAs specific for ALK 3.Induction of apoptosis in H2228 and H3122 cells by crizotinib 4.In MANA2 cells, HGF and EGFR ligands trigger ALK inhibitor resistance via Met and EGFR, respectively