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Phase II open-label study of single-agent hydroxyurea for treatment of mast cell tumours in dogs*
Phase II open-label study of single-agent hydroxyurea for treatment of mast cell tumours in dogs*
- Source :
- Veterinary and Comparative Oncology. 8:103-111
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- This prospective study evaluated the efficacy and safety of hydroxyurea (HU) in dogs with measurable mast cell tumours (MCTs). Dogs were treated with HU at 60 mg kg(-1)per os q24h for 14 days then 30 mg kg(-1) q24h thereafter or until MCT recurrence. Forty-six dogs were enrolled. The overall response rate was 28%. Two dogs had a complete response (CR) for 256 and 448 days, respectively. Eleven dogs had a partial response for a median duration of 46 days (range, 28-189 days). Grade 2 to 4 neutropenia occurred in eight dogs and grade 4 thrombocytopenia in two. Grade 3-4 anaemia occurred in seven dogs; overall, there was a significant decrease in haematocrit after treatment with HU. The median drop in haematocrit was 10%. This study demonstrated that HU has activity in the treatment of MCTs with mild anaemia being the primary adverse event.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Antineoplastic Agents
Neutropenia
Gastroenterology
Drug Administration Schedule
Hydroxycarbamide
Leukocyte Count
Dogs
Pharmacotherapy
Open label study
hemic and lymphatic diseases
Internal medicine
medicine
Animals
Hydroxyurea
Dog Diseases
Prospective Studies
Adverse effect
Prospective cohort study
Mastocytoma, Skin
Chemotherapy
General Veterinary
business.industry
medicine.disease
Mast cell
Thrombocytopenia
Surgery
Treatment Outcome
medicine.anatomical_structure
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 14765829 and 14765810
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Veterinary and Comparative Oncology
- Accession number :
- edsair.doi.dedup.....1313f76796deb216e6f47ece58426823
- Full Text :
- https://doi.org/10.1111/j.1476-5829.2010.00211.x