Back to Search
Start Over
Lattice defects induce microtubule self-renewal
- Source :
- Nature Physics, Nature Physics, Nature Publishing Group, 2019, 15 (8), pp.830-838. ⟨10.1038/s41567-019-0542-4⟩, Nature Physics, 2019, 15 (8), pp.830-838. ⟨10.1038/s41567-019-0542-4⟩, Nature Physics, Nature Publishing Group, 2019, 15 (15), pp.830-838. ⟨10.1038/s41567-019-0542-4⟩, Nature physics
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- The dynamic instability of microtubules is powered by the addition and removal of tubulin dimers at the ends of the microtubule. Apart from the end, the microtubule shaft is not considered to be dynamic. However recent evidence suggests that free dimers can be incorporated into the shaft of a microtubule damaged by mechanical stress. Here we explored whether dimer exchange was a core property of the microtubule lattice independently of any external constraint. We found that dimers can be removed from and incorporated into the lattice at sites along the microtubule shaft. Furthermore, we showed by experiment and by modeling that rapid dimer renewal requires structural defects in the lattice, which occur in fast growing microtubules. Hence long-lived microtubules have the capacity to self-renew despite their apparent stability and thereby can potentially regulate signaling pathways and structural rearrangements associated with tubulin-dimer exchange at sites along their entire length.
- Subjects :
- Lattice dynamics
Dimer
[SDV]Life Sciences [q-bio]
General Physics and Astronomy
Crystal structure
Self renewal
Instability
01 natural sciences
Microtubules
Article
Lattice vibrations
010305 fluids & plasmas
Quantitative Biology::Subcellular Processes
03 medical and health sciences
chemistry.chemical_compound
Microtubule
Lattice (order)
0103 physical sciences
010306 general physics
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Physics
Thermal forces
0303 health sciences
Structural defect
biology
Chemistry
030302 biochemistry & molecular biology
Model mechanisms
Dissipative dynamics
Dynamics
Tubulin
Lattice defects
biology.protein
Biophysics
Lattice structures
Passive materials
Defects
Subjects
Details
- Language :
- English
- ISSN :
- 17452473 and 14764636
- Database :
- OpenAIRE
- Journal :
- Nature Physics, Nature Physics, Nature Publishing Group, 2019, 15 (8), pp.830-838. ⟨10.1038/s41567-019-0542-4⟩, Nature Physics, 2019, 15 (8), pp.830-838. ⟨10.1038/s41567-019-0542-4⟩, Nature Physics, Nature Publishing Group, 2019, 15 (15), pp.830-838. ⟨10.1038/s41567-019-0542-4⟩, Nature physics
- Accession number :
- edsair.doi.dedup.....12f64667774a939d2da731b8f49214c2