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Protein kinase inhibitor-based cancer therapies: Considering the potential of nitric oxide (NO) to improve cancer treatment
- Source :
- Biochemical Pharmacology, Biochemical Pharmacology, 2020, 176, pp.113855-. ⟨10.1016/j.bcp.2020.113855⟩
- Publication Year :
- 2019
-
Abstract
- The deregulation of a wide variety of protein kinases is associated with cancer cell initiation and tumor progression. Owing to their indispensable function in signaling pathways driving malignant cell features, protein kinases constitute major therapeutic targets in cancer. Over the past two decades, intense efforts in drug development have been dedicated to this field. The development of protein kinase inhibitors (PKIs) have been a real breakthrough in targeted cancer therapy. Despite obvious successes across patients with different types of cancer, the development of PKI resistance still prevails. Combination therapies are part of a comprehensive approach to address the problem of drug resistance. The therapeutic use of nitric oxide (NO) donors to bypass PKI resistance in cancer has never been tested in clinic yet but several arguments suggest that the combination of PKIs and NO donors may exert a potential anticancer effect. The present review summarized the current state of knowledge on common targets to both PKIs and NO. Herein, we attempt to provide the rationale underlying a potential combination of PKIs and NO donors for future directions and design of new combination therapies in cancer.
- Subjects :
- 0301 basic medicine
medicine.drug_class
[SDV]Life Sciences [q-bio]
Nitric Oxide
Biochemistry
03 medical and health sciences
0302 clinical medicine
Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Medicine
Humans
Nitric Oxide Donors
Molecular Targeted Therapy
Protein kinase A
Protein Kinase Inhibitors
Pharmacology
business.industry
Kinase
Cancer
Protein kinase inhibitor
medicine.disease
3. Good health
030104 developmental biology
Drug development
Tumor progression
Drug Resistance, Neoplasm
030220 oncology & carcinogenesis
Cancer cell
Cancer research
Signal transduction
business
Protein Kinases
Signal Transduction
Subjects
Details
- ISSN :
- 18732968 and 00062952
- Volume :
- 176
- Database :
- OpenAIRE
- Journal :
- Biochemical pharmacology
- Accession number :
- edsair.doi.dedup.....12f0ae42be59febc5f2ec7ea5e5f147a