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A novel framework for spatial normalization of dose distributions in voxel-based analyses of brain irradiation outcomes
A novel framework for spatial normalization of dose distributions in voxel-based analyses of brain irradiation outcomes
- Source :
- Physica medica (Testo stamp.) 69 (2020): 164–169. doi:10.1016/j.ejmp.2019.12.017, info:cnr-pdr/source/autori:Monti, S.; Paganelli, C.; Buizza, G.; Preda, L.; Valvo, F.; Baroni, G.; Palma, G.; Cella, L./titolo:A novel framework for spatial normalization of dose distributions in voxel-based analyses of brain irradiation outcomes/doi:10.1016%2Fj.ejmp.2019.12.017/rivista:Physica medica (Testo stamp.)/anno:2020/pagina_da:164/pagina_a:169/intervallo_pagine:164–169/volume:69
- Publication Year :
- 2020
-
Abstract
- To devise a novel Spatial Normalization framework for Voxel-based analysis (VBA) in brain radiotherapy. VBAs rely on accurate spatial normalization of different patients' planning CTs on a common coordinate system (CCS). The cerebral anatomy, well characterized by MRI, shows instead poor contrast in CT, resulting in potential inaccuracies in VBAs based on CT alone.We analyzed 50 meningioma patients treated with proton-therapy, undergoing planning CT and T1-weighted (T1w) MRI. The spatial normalization pipeline based on MR and CT images consisted in: intra-patient registration of CT to T1w, inter-patient registration of T1w to MNI space chosen as CCS, doses propagation to MNI. The registration quality was compared with that obtained by Statistical Parametric Mapping software (SPM), used as benchmark. To evaluate the accuracy of dose normalization, the dose organ overlap (DOO) score was computed on gray matter, white matter and cerebrospinal fluid before and after normalization. In addition, the trends in the DOOs distribution were investigated by means of cluster analysis.The registration quality was higher for the proposed method compared to SPM (p 0.001). The DOO scores showed a significant improvement after normalization (p 0.001). The cluster analysis highlighted 2 clusters, with one of them including the majority of data and exhibiting acceptable DOOs.Our study presents a robust tool for spatial normalization, specifically tailored for brain dose VBAs. Furthermore, the cluster analysis provides a formal criterion for patient exclusion in case of non-acceptable normalization results. The implemented framework lays the groundwork for future reliable VBAs in brain irradiation studies.
- Subjects :
- Adult
Brain toxicity
Adolescent
Computer science
Brain radiotherapy
Biophysics
Normalization (image processing)
General Physics and Astronomy
Contrast Media
Dose distribution
computer.software_genre
Statistical parametric mapping
030218 nuclear medicine & medical imaging
White matter
03 medical and health sciences
Young Adult
0302 clinical medicine
Voxel
Voxel based analysis
medicine
Image Processing, Computer-Assisted
Cluster Analysis
Humans
Radiology, Nuclear Medicine and imaging
Radiometry
Proton therapy
Aged
Models, Statistical
business.industry
Brain Neoplasms
Brain
Reproducibility of Results
Pattern recognition
General Medicine
Middle Aged
Magnetic Resonance Imaging
medicine.anatomical_structure
030220 oncology & carcinogenesis
Spatial normalization
Artificial intelligence
business
Meningioma
Tomography, X-Ray Computed
Dose spatial normalization
computer
Software
MRI
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Physica medica (Testo stamp.) 69 (2020): 164–169. doi:10.1016/j.ejmp.2019.12.017, info:cnr-pdr/source/autori:Monti, S.; Paganelli, C.; Buizza, G.; Preda, L.; Valvo, F.; Baroni, G.; Palma, G.; Cella, L./titolo:A novel framework for spatial normalization of dose distributions in voxel-based analyses of brain irradiation outcomes/doi:10.1016%2Fj.ejmp.2019.12.017/rivista:Physica medica (Testo stamp.)/anno:2020/pagina_da:164/pagina_a:169/intervallo_pagine:164–169/volume:69
- Accession number :
- edsair.doi.dedup.....12e63afbfa84ef3c6a84b604150d3dfa
- Full Text :
- https://doi.org/10.1016/j.ejmp.2019.12.017