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Highly flexible and degradable dual setting systems based on PEG-hydrogels and brushite cement
- Source :
- Acta biomaterialia. 79
- Publication Year :
- 2018
-
Abstract
- With respect to the composition of natural bone, we established a degradable dual setting system of different poly(ethylene glycol) (PEG)-based hydrogels combined with a brushite cement. The idea was to reinforce the inorganic calcium phosphate mineral phase with an organic, polymeric phase to alter the cement’s properties towards ductility and elasticity. Extremely flexible samples were produced via this dual setting approach with a fully reversible elasticity of the samples containing high molecular weight PEG-based hydrogel precursors. Using the decalcifying agent EDTA, the whole inorganic phase was dissolved due to Ca2+-complexation and dimensionally stable hydrogels were obtained, indicating a homogenous polymeric phase within the composites. This was also confirmed by SEM-analysis, where no discontinuities or agglomerations of the phase were observed. Additional XRD-measurements proved a significant influence of the coherent polymeric matrix on the conversion from β-TCP/MCPA to brushite with a decrease in signal intensity. The results confirmed a parallelly running process of setting reaction and gelation without an inhibition of the conversion to brushite and the formation of interpenetrating networks of hydrogel and cement. The strengths of this newly developed dual setting system are based on the material degradability as well as flexibility, which can be a promising tool for bone regeneration applications in non-load bearing craniomaxillofacial defects. Statement of Significance Brushite based calcium phosphate cements (CPCs) are known as bone replacement materials, which degrade in vivo and are replaced by native bone. However, the pure inorganic material shows a brittle fracture behavior. Here, the addition of a polymeric phase can influence the mechanical properties to create more ductile and flexible materials. This polymeric phase should ideally form during cement setting by a polymerization reaction to achieve high polymer loads without altering cement viscosity and it should be degradable in vivo similar to the cement itself. Therefore, we developed a dual setting system based on simultaneous cement setting of brushite and lactide modified poly(ethylene glycol) dimethacrylate (PEG-PLLA-DMA)-based hydrogel. It was evident that the gels form a continuous phase within the cement after radical polymerization with a strong reduction of cement brittleness.
- Subjects :
- Calcium Phosphates
Materials science
Compressive Strength
Proton Magnetic Resonance Spectroscopy
Radical polymerization
Biomedical Engineering
Biocompatible Materials
02 engineering and technology
010402 general chemistry
01 natural sciences
Biochemistry
Polyethylene Glycols
Biomaterials
chemistry.chemical_compound
X-Ray Diffraction
Elastic Modulus
PEG ratio
Materials Testing
Spectroscopy, Fourier Transform Infrared
Brushite
Bone regeneration
Molecular Biology
Cement
technology, industry, and agriculture
Bone Cements
Hydrogels
General Medicine
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
0104 chemical sciences
Solutions
Chemical engineering
Polymerization
chemistry
Self-healing hydrogels
Methacrylates
Stress, Mechanical
0210 nano-technology
Ethylene glycol
Biotechnology
Subjects
Details
- ISSN :
- 18787568
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- Acta biomaterialia
- Accession number :
- edsair.doi.dedup.....12e41a58712f8516639913a67892d213