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Vasogenic cerebral edema associated with the disability in activities of daily living in patients with chronic obstructive pulmonary disease
- Source :
- Brain and Behavior
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Introduction The aim of this study was to explore whether patients with chronic obstructive pulmonary disease (COPD) develop vasogenic cerebral edema, and whether this edema contributes to the COPD‐related disability. Methods Eighteen stable patients with COPD and 17 matched healthy volunteers were enrolled. Apparent diffusion coefficient (ADC) values were calculated by voxel‐based analysis using DTI‐Studio software based on diffusion tensor imaging. COPD‐related disability was calculated using activities of daily living (ADL) scale. Results In patients with COPD, ADC increased in the white matter fiber tracts including the bilateral anterior cingulum and posterior corpus callosum and in the white matter fibers connecting the bilateral insular cortices, sub‐lobar cortices, and pars triangularis cortices and the left rectus and olfactory gyrus. However, after further controlling for cigarette smoking, the difference in ADC values in the posterior corpus callosum between groups disappeared. Patients with COPD had significantly higher scores in ADL than that in controls. Moreover, ADL scores were positively correlated with the increased regional ADC values. Conclusion Vasogenic cerebral edema occurs in patients with COPD. Cigarette smoking may be a risk factor for COPD‐related vasogenic edema. Vasogenic cerebral edema may be related to the COPD‐related ADL impairment.
- Subjects :
- Male
medicine.medical_specialty
Brain Edema
Corpus callosum
Cerebral edema
White matter
Pulmonary Disease, Chronic Obstructive
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Edema
Internal medicine
Activities of Daily Living
medicine
COPD
Humans
Effective diffusion coefficient
Cingulum (brain)
Disabled Persons
Original Research
Aged
Brain Mapping
business.industry
Brain
medicine.disease
respiratory tract diseases
cerebral edema
Diffusion Tensor Imaging
medicine.anatomical_structure
030228 respiratory system
DTI
Cardiology
apparent diffusion coefficient
Female
medicine.symptom
business
030217 neurology & neurosurgery
Diffusion MRI
Subjects
Details
- ISSN :
- 21623279
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Brain and Behavior
- Accession number :
- edsair.doi.dedup.....12daba8d85ca409d93a17e441ba272f4