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Feed-forward excitation of striatal neuron activity by frontal cortical activation of nitric oxide signaling in vivo
- Source :
- The European journal of neuroscience. 27(7)
- Publication Year :
- 2008
-
Abstract
- The gaseous neurotransmitter nitric oxide plays an important role in the modulation of corticostriatal synaptic transmission. This study examined the impact of frontal cortex stimulation on striatal nitric oxide efflux and neuron activity in urethane-anesthetized rats using amperometric microsensor and single-unit extracellular recordings, respectively. Systemic administration of the neuronal nitric oxide synthase inhibitor 7-nitroindazole decreased spontaneous spike activity without affecting activity evoked by single-pulse stimulation of the ipsilateral cortex. Train (30 Hz) stimulation of the contralateral frontal cortex transiently increased nitric oxide efflux in a robust and reproducible manner. Evoked nitric oxide efflux was attenuated by systemic administration of 7-nitroindazole and the non-selective nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester. Train stimulation of the contralateral cortex, in a manner identical to that used to evoke nitric oxide efflux, had variable effects on spike activity assessed during the train stimulation trial, but induced a short-term depression of cortically evoked activity in the first post-train stimulation trial. Interestingly, 7-nitroindazole potently decreased cortically evoked activity recorded during the train stimulation trial. Moreover, the short-term depression of spike activity induced by train stimulation was enhanced following pretreatment with 7-nitroindazole and attenuated after systemic administration of the dopamine D2 receptor antagonist eticlopride. These results demonstrate that robust activation of frontal cortical afferents in the intact animal activates a powerful nitric oxide-mediated feed-forward excitation which partially offsets concurrent D2 receptor-mediated short-term inhibitory influences on striatal neuron activity. Thus, nitric oxide signaling is likely to play an important role in the integration of corticostriatal sensorimotor information in striatal networks.
- Subjects :
- Male
neuronal nitric oxide synthase
Stimulation
Neurotransmission
Nitric Oxide
Inhibitory postsynaptic potential
Nitric oxide
term plasticity
Rats, Sprague-Dawley
corticostriatal
chemistry.chemical_compound
Eticlopride
Neural Pathways
medicine
Animals
rat
Neurotransmitter
10194 Institute of Neuroinformatics
Cerebral Cortex
Feedback, Physiological
Neurons
short
biology
Chemistry
General Neuroscience
2800 General Neuroscience
Corpus Striatum
Electric Stimulation
nitrergic transmission
Rats
Nitric oxide synthase
medicine.anatomical_structure
biology.protein
570 Life sciences
Neuron
Neuroscience
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 14609568 and 0953816X
- Volume :
- 27
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- The European journal of neuroscience
- Accession number :
- edsair.doi.dedup.....12d99f8acdafb86bea491a1ed2489798