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Quantitative Trait Loci for Metabolic Syndrome in the Hypertension Genetic Epidemiology Network Study
- Source :
- Obesity Research. 13:1885-1890
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- As part of the Hypertension Genetic Epidemiology Network study, genome scans were performed in two ethnicities on the categorical metabolic syndrome (MetS). Genome scans were performed also on the factor scores produced by factor analysis (quantitative MetS). Heritabilities were highest for the obesity-insulin (INS) factor and lowest for blood pressure (BP) and central obesity. Seventeen unique putative quantitative trait loci (QTLs) yielded logarithm of the odds ratio (LOD) scores in excess of 1.7, 8 for blacks and 9 for whites. Important QTL findings in whites included an LOD score of 3.19 on chromosome 15q15 for the BP factor, 3.08 on chromosome 8p23 for the lipids-INS factor, and 3.07 on chromosome 3p26 for the obesity-INS factor. In blacks, after excluding type 2 diabetics, important QTLs were identified, including an LOD score of 2.77 on 13p12 for the obesity-INS factor and 2.63 on chromosome 11q24 for the lipids-INS factor. Categorical MetS had lower results than quantitative MetS. Notably, several loci identified overlap with those identified in other studies for a single or group of traits. The most promising candidate loci on 11q24 for lipids-INS and 13p12 for obesity-INS in blacks, 8p23 for lipids-INS, 14q24 for obesity-INS, and 15q15 for BP in whites warrant further investigation.
- Subjects :
- Male
Genotype
Genetic Linkage
Endocrinology, Diabetes and Metabolism
Quantitative Trait Loci
Black People
Medicine (miscellaneous)
Blood Pressure
Type 2 diabetes
Quantitative trait locus
Biology
White People
Cohort Studies
Endocrinology
Genetic linkage
medicine
Humans
Genetic Predisposition to Disease
Obesity
Chromosomes, Human, Pair 14
Metabolic Syndrome
Genetics
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 11
Public Health, Environmental and Occupational Health
Chromosome Mapping
Chromosome
Odds ratio
medicine.disease
Diabetes Mellitus, Type 2
Hypertension
Female
Chromosomes, Human, Pair 3
Lod Score
Metabolic syndrome
Chromosomes, Human, Pair 8
Food Science
Subjects
Details
- ISSN :
- 10717323
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Obesity Research
- Accession number :
- edsair.doi.dedup.....12d729519cfb8182f6434de1cf99f9b3
- Full Text :
- https://doi.org/10.1038/oby.2005.231