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A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study
- Source :
- Sci China Life Sci
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Fulminant myocarditis (FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen (LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR (81 cases), which includes (i) mechanical life support (positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation), (ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and (iii) application of neuraminidase inhibitors, and those receiving conventional treatment (88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients (26.0%) died in hospitals. In-hospital mortality was 3.7% (3/81) for LSBCTR group and 46.6% (41/88) for traditional treatment (P
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Myocarditis
medicine.medical_treatment
Fulminant
Population
Immunoglobulins
Article
General Biochemistry, Genetics and Molecular Biology
Young Adult
03 medical and health sciences
Extracorporeal Membrane Oxygenation
0302 clinical medicine
Drug Therapy
Internal medicine
Outcome Assessment, Health Care
medicine
Extracorporeal membrane oxygenation
Humans
Hospital Mortality
education
Glucocorticoids
General Environmental Science
education.field_of_study
biology
business.industry
Cardiogenic shock
Middle Aged
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
Life support
biology.protein
Heart Transplantation
Female
Heart-Assist Devices
Immunomodulation Therapy
General Agricultural and Biological Sciences
business
Neuraminidase
Subjects
Details
- ISSN :
- 18691889 and 16747305
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Science China Life Sciences
- Accession number :
- edsair.doi.dedup.....12c75b66ab417edd4f21069c8e82bef4